Journal article
Navigating hyperammonemic encephalopathy: Continuous renal replacement therapy in a urea cycle defect secondary to fibrolamellar hepatocellular carcinoma
Journal of Onco-Nephrology, Vol.9(2), pp.42-47
06/2025
DOI: 10.1177/23993693251340194
Abstract
Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare liver cancer variant, accounting for less than 1% of primary hepatic malignancies, predominantly affecting young adults. This case report presents a 24-year-old patient with altered mental status, ultimately diagnosed with metastatic FL-HCC and secondary hyperammonemic encephalopathy, a rare but critical complication. Management involved continuous renal replacement therapy (CRRT), ammonia-scavenging agents, and targeted radiotherapy for the primary tumor. This report elucidates the clinical presentation of FL-HCC, explores the pathophysiology of hyperammonemia-induced encephalopathy, and discusses management strategies, emphasizing the therapeutic role of dialysis modalities.
Details
- Title: Subtitle
- Navigating hyperammonemic encephalopathy: Continuous renal replacement therapy in a urea cycle defect secondary to fibrolamellar hepatocellular carcinoma
- Creators
- Mohamed F Mudarres - University of Iowa Hospitals and ClinicsBenjamin Griffin - University of IowaBahjat Azrieh - University of Iowa Hospitals and ClinicsAllyson Rose - University of Iowa Hospitals and ClinicsNada Youssef - University of Iowa Hospitals and ClinicsNaga Sumanth Gopireddy - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Journal of Onco-Nephrology, Vol.9(2), pp.42-47
- DOI
- 10.1177/23993693251340194
- ISSN
- 2399-3693
- eISSN
- 2399-3707
- Publisher
- Sage
- Language
- English
- Electronic publication date
- 05/14/2025
- Date published
- 06/2025
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984824296902771
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