Journal article
Navigating the Unique Challenge of Pulmonary Hypertension From Left-to-Right PDA Shunts in Two Cases of Congenital Diaphragmatic Hernia
Echocardiography (Mount Kisco, N.Y.), Vol.43(1), e70396
01/2026
DOI: 10.1111/echo.70396
PMID: 41553100
Abstract
Pulmonary hypertension (PH) in congenital diaphragmatic hernia (CDH) is nearly universal yet incredibly complex. A patent ductus arteriosus (PDA) is increasingly utilized to both monitor echocardiographically and manage CDH-PH. However, as pulmonary pressures are driven by both vascular resistance and blood flow, there is a risk that as the former improves, PH may in fact worsen from pathologic left-to-right (LtR) PDA shunting. Herein, we describe two cases of neonatal CDH whose PH was complicated by pathologic LtR PDA shunting and pulmonary overcirculation and improved following resolution of the transductal shunt, highlighting the underrecognized risk of pathologic PDA shunts in CDH.
Details
- Title: Subtitle
- Navigating the Unique Challenge of Pulmonary Hypertension From Left-to-Right PDA Shunts in Two Cases of Congenital Diaphragmatic Hernia
- Creators
- John T Wren Jr - University of Iowa, NeonatologyRhucha Joshi - Children's Hospital of Orange CountyPatrick J McNamara - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Echocardiography (Mount Kisco, N.Y.), Vol.43(1), e70396
- DOI
- 10.1111/echo.70396
- PMID
- 41553100
- NLM abbreviation
- Echocardiography
- ISSN
- 0742-2822
- eISSN
- 1540-8175
- Publisher
- Wiley
- Language
- English
- Date published
- 01/2026
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9985130217202771
Metrics
1 Record Views