Journal article
Navigator Flip Angle Optimization for Free-Breathing T1-Weighted Hepatobiliary Phase Imaging With Gadoxetic Acid
Journal of magnetic resonance imaging, Vol.40(5), pp.1129-1136
11/01/2014
DOI: 10.1002/jmri.24480
PMID: 24214890
Abstract
Purpose: To characterize and optimize the navigator-flip angle (FA), and the influence of imaging-FA on optimizing liver/lung contrast of the navigator profile, while avoiding visible navigator saturation artifacts, for hepatobiliary phase gadoxetic acid-enhanced MRI.
Materials and Methods: Ten volunteers; six men, four women; ages 37.1 +/- 11.0 years underwent navigator-gated three-dimensional (3D) -spoiled-gradient-echo sequences in randomized combinations of imaging-FA (10 degrees/30 degrees) and navigator-FA (10-90 degrees) before contrast and 20 min after injection of gadoxetic acid at 3 Tesla. The signal intensities of the liver and lung were measured from navigator profiles. Furthermore, the intensity of saturation artifacts for each navigator FA was quantified using measurements of relative contrast at the artifact location.
Results: For the postcontrast images, the optimal navigator FA was 90 degrees. However, saturation artifacts were highly dependent on the imaging-FA and the presence of gadolinium contrast. A smaller imaging-FA of 10 degrees led to greater saturation artifacts for both pre- and postcontrast, and saturation artifacts worsen with increasing navigator-FA. Using a higher imaging-FA of 30 degrees, saturation artifacts are ignorable over the entire range of navigator-FA.
Conclusion: For navigator-gated gadoxetic acid-enhanced hepatobiliary imaging, navigator-FA of 90 degrees and imaging-FA of 30 degrees provide an optimal balance with maximum navigator liver/lung contrast while avoiding visible imaging saturation artifacts.
Details
- Title: Subtitle
- Navigator Flip Angle Optimization for Free-Breathing T1-Weighted Hepatobiliary Phase Imaging With Gadoxetic Acid
- Creators
- Jens-P. Kuehn - Ernst Moritz Arndt Univ Greifswald, Dept Radiol & Neuroradiol, D-17475 Greifswald, GermanyJames H. HolmesAnja C. S. BrauYuji IwadateDiego Hernando - University of Wisconsin–MadisonScott B. Reeder - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Journal of magnetic resonance imaging, Vol.40(5), pp.1129-1136
- DOI
- 10.1002/jmri.24480
- PMID
- 24214890
- NLM abbreviation
- J Magn Reson Imaging
- ISSN
- 1053-1807
- eISSN
- 1522-2586
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- RC1EB010384 / NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) R01DK088925 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) FKZ 03IS2061A / German Federal Ministry of Education and Research; Federal Ministry of Education & Research (BMBF) RC1 EB010384; R01 DK083380; R01 DK088925 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA UG 09 033 / Ministry of Cultural Affairs of the Federal State of Mecklenburg-West Pomerania
- Language
- English
- Date published
- 11/01/2014
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology
- Record Identifier
- 9984295027002771
Metrics
9 Record Views