Journal article
Near-infrared fluorescence goggle system with complementary metal–oxide–semiconductor imaging sensor and see-through display
Journal of biomedical optics, Vol.18(10), pp.101303-101303
Special Section on Fluorescence Molecular Imaging Honoring Prof. Roger Tsien, a Pioneer in Biomedical Optics
10/2013
DOI: 10.1117/1.JBO.18.10.101303
PMCID: PMC3667841
PMID: 23728180
Abstract
We have developed a near-infrared (NIR) fluorescence goggle system based on the complementary metal–oxide–semiconductor active pixel sensor imaging and see-through display technologies. The fluorescence goggle system is a compact wearable intraoperative fluorescence imaging and display system that can guide surgery in real time. The goggle is capable of detecting fluorescence of indocyanine green solution in the picomolar range. Aided by NIR quantum dots, we successfully used the fluorescence goggle to guide sentinel lymph node mapping in a rat model. We further demonstrated the feasibility of using the fluorescence goggle in guiding surgical resection of breast cancer metastases in the liver in conjunction with NIR fluorescent probes. These results illustrate the diverse potential use of the goggle system in surgical procedures.
Details
- Title: Subtitle
- Near-infrared fluorescence goggle system with complementary metal–oxide–semiconductor imaging sensor and see-through display
- Creators
- Yang Liu - University of WashingtonRaphael Njuguna - University of WashingtonThomas Matthews - University of WashingtonWalter J Akers - University of WashingtonGail P Sudlow - University of WashingtonSuman Mondal - University of WashingtonRui Tang - University of WashingtonViktor Gruev - University of WashingtonSamuel Achilefu - University of Washington
- Resource Type
- Journal article
- Publication Details
- Journal of biomedical optics, Vol.18(10), pp.101303-101303
- Series
- Special Section on Fluorescence Molecular Imaging Honoring Prof. Roger Tsien, a Pioneer in Biomedical Optics
- DOI
- 10.1117/1.JBO.18.10.101303
- PMID
- 23728180
- PMCID
- PMC3667841
- NLM abbreviation
- J Biomed Opt
- ISSN
- 1083-3668
- eISSN
- 1560-2281
- Publisher
- Society of Photo-Optical Instrumentation Engineers
- Grant note
- K01RR026095 / National Center for Research Resources FA9550-10-1-0121; FA9550-12-1-0321 / Air Force Office of Scientific Research NCI R01 CA171651; NIBIB R01 EB008111 / National Institutes of Health W81XWH-11-1-0059 / US Department of Defense Breast Cancer Research Program Predoctoral Award
- Language
- English
- Date published
- 10/2013
- Academic Unit
- Electrical and Computer Engineering
- Record Identifier
- 9984197287102771
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