Journal article
Necroptosis of Dendritic Cells Promotes Activation of γδ T cells
Journal of innate immunity, Vol.8(5), pp.479-492
2016
DOI: 10.1159/000446498
PMCID: PMC5002261
PMID: 27431410
Abstract
γδ T cells function at the interface between innate and adaptive immunity and have well-demonstrated roles in response to infection, autoimmunity, and tumors. A common characteristic of these seemingly disparate conditions may be cellular stress or death. Yet, the conditions under which ligands for γδ T cells are induced or exposed remain largely undefined. We now observe that induction of necroptosis of murine or human dendritic cells by inhibition of caspase activity paradoxically augments their ability to activate γδ T cells. Furthermore, upregulation of the stabilizer of caspase-8 activity, c-FLIP, by IL-4 not only greatly reduced the susceptibility of dendritic cells to necroptosis, but also considerably decreased their ability to activate γδ T cells. Collectively these findings suggest that induction of necroptosis in dendritic cells upregulates or exposes expression of γδ T cell ligands, and supports the view that γδ T cells function in the immune surveillance of cell stress.
Details
- Title: Subtitle
- Necroptosis of Dendritic Cells Promotes Activation of γδ T cells
- Creators
- Cheryl C Collins - Vermont Center for Immunology and Infectious Diseases, Department of Medicine, The University of Vermont College of Medicine, Burlington, VT, USAHong Wang - Division of Immunology, Department of Internal Medicine, Iowa City, IA, USAKathleen Bashant - Vermont Center for Immunology and Infectious Diseases, Department of Medicine, The University of Vermont College of Medicine, Burlington, VT, USACraig T Morita - Division of Immunology, Department of Internal Medicine, Iowa City, IA, USACuixia Erikson - Vermont Center for Immunology and Infectious Diseases, Department of Medicine, The University of Vermont College of Medicine, Burlington, VT, USAPhyu Myat Thwe - Vermont Center for Immunology and Infectious Diseases, Department of Medicine, The University of Vermont College of Medicine, Burlington, VT, USAKaren A Fortner - Vermont Center for Immunology and Infectious Diseases, Department of Medicine, The University of Vermont College of Medicine, Burlington, VT, USARalph C Budd - Vermont Center for Immunology and Infectious Diseases, Department of Medicine, The University of Vermont College of Medicine, Burlington, VT, USA
- Resource Type
- Journal article
- Publication Details
- Journal of innate immunity, Vol.8(5), pp.479-492
- DOI
- 10.1159/000446498
- PMID
- 27431410
- PMCID
- PMC5002261
- ISSN
- 1662-811X
- eISSN
- 1662-8128
- Language
- English
- Date published
- 2016
- Academic Unit
- Immunology; Internal Medicine
- Record Identifier
- 9984094354602771
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