Necrotizing Enterocolitis Is Not Associated With Sequence Variants in Antioxidant Response Genes in Premature Infants

Venkatesh Sampath; Daniel Helbling; Heather Menden; David Dimmock; Neil P Mulrooney; Jeffrey C Murray; John M Dagle; Jeffery S Garland

doi:10.1097/MPG.0000000000000988

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Necrotizing Enterocolitis Is Not Associated With Sequence Variants in Antioxidant Response Genes in Premature Infants

Journal article

Open access

Peer reviewed

Necrotizing Enterocolitis Is Not Associated With Sequence Variants in Antioxidant Response Genes in Premature Infants

Venkatesh Sampath, Daniel Helbling, Heather Menden, David Dimmock, Neil P Mulrooney, Jeffrey C Murray, John M Dagle and Jeffery S Garland

Journal of pediatric gastroenterology and nutrition, Vol.62(3), pp.420-423

03/2016

DOI: 10.1097/MPG.0000000000000988

PMCID: PMC5055643

PMID: 26426434

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Abstract

Reactive oxygen species mediate intestinal injury in necrotizing enterocolitis (NEC), and yet the contribution of antioxidant response (ARE) gene polymorphisms to NEC risk remains unknown. Premature infants recruited in a multicenter study were genotyped for 6 ARE variants. Among 637 infants, 52 had NEC, and 22 developed surgical NEC. Gestational age <28 weeks (P < 0.02) and African American race (P = 0.03) were associated with NEC. The NFE2L2 (rs6721961), SOD2 (rs4880), GSTP1 (rs1695), NQO1 (rs1800566), GCLC (rs17883901), and HMOX1 (rs2071747) variants were not associated with medical or surgical NEC. This study does not support a role for common deleterious ARE variants in NEC.

Genetic Predisposition to Disease

Prospective Studies

Enterocolitis, Necrotizing - genetics

Humans

Genotype

Infant

Male

Gestational Age

Antioxidants

Genetic Variation

Infant, Premature

Antioxidant Response Elements - genetics

Female

NF-E2-Related Factor 2 - genetics

Polymorphism, Single Nucleotide

Infant, Newborn

Cohort Studies

Details

Title: Subtitle: Necrotizing Enterocolitis Is Not Associated With Sequence Variants in Antioxidant Response Genes in Premature Infants
Creators: Venkatesh Sampath - Department of Pediatrics, Medical College of Wisconsin †Children's Research Institute, Children's Hospital and Health Systems, Milwaukee, WI ‡Children's Hospitals and Clinics of Minnesota, Minneapolis §Department of Pediatrics, Iowa Children's Hospital, University of Iowa, Iowa City ¶Department of Pediatrics, Wheaton Franciscan Health Care, St Joseph Hospital, Milwaukee, WI
Daniel Helbling
Heather Menden
David Dimmock
Neil P Mulrooney
Jeffrey C Murray
John M Dagle
Jeffery S Garland
Resource Type: Journal article
Publication Details: Journal of pediatric gastroenterology and nutrition, Vol.62(3), pp.420-423
DOI: 10.1097/MPG.0000000000000988
PMID: 26426434
PMCID: PMC5055643
NLM abbreviation: J Pediatr Gastroenterol Nutr
ISSN: 0277-2116
eISSN: 1536-4801
Publisher: United States
Grant note: R01 HD057192 / NICHD NIH HHS R01 HD052953 / NICHD NIH HHS 8KL2TR000056 / NCATS NIH HHS KL2 TR000056 / NCATS NIH HHS KL2 TR001438 / NCATS NIH HHS
Language: English
Date published: 03/2016
Academic Unit: Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Biochemistry and Molecular Biology; Dental Research; Neonatology
Record Identifier: 9984025284902771

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