Journal article
Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions
Cell death and differentiation, Vol.17(1), pp.68-77
01/2010
DOI: 10.1038/cdd.2009.84
PMCID: PMC2818775
PMID: 19557014
Abstract
The Nedd4 (
n
eural precursor cell-
e
xpressed
d
evelopmentally
d
ownregulated gene 4) family of ubiquitin ligases (E3s) is characterized by a distinct modular domain architecture, with each member consisting of a C2 domain, 2–4 WW domains, and a HECT-type ligase domain. Of the nine mammalian members of this family, Nedd4 and its close relative, Nedd4-2, represent the ancestral ligases with strong similarity to the yeast, Rsp5. In
Saccharomyces cerevisiae
Rsp5 has a key role in regulating the trafficking, sorting, and degradation of a large number of proteins in multiple cellular compartments. However, in mammals the Nedd4 family members, including Nedd4 and Nedd4-2, appear to have distinct functions, thereby suggesting that these E3s target specific proteins for ubiquitylation. In this article we focus on the biology and emerging functions of Nedd4 and Nedd4-2, and review recent
in vivo
studies on these E3s.
Details
- Title: Subtitle
- Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions
- Creators
- B Yang - Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USAS Kumar - Centre for Cancer Biology, SA Pathology and Hanson Institute, Adelaide, SA 5000, Australia
- Resource Type
- Journal article
- Publication Details
- Cell death and differentiation, Vol.17(1), pp.68-77
- DOI
- 10.1038/cdd.2009.84
- PMID
- 19557014
- PMCID
- PMC2818775
- ISSN
- 1350-9047
- eISSN
- 1476-5403
- Language
- English
- Date published
- 01/2010
- Academic Unit
- BioVentures Center
- Record Identifier
- 9984083996802771
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