Journal article
Negative effects of alcohol intake and estrogen deficiency combination on osseointegration in a rat model
The Journal of oral implantology, Vol.37(6), pp.633-639
12/2011
DOI: 10.1563/AAID-JOI-D-10-00048
PMID: 21504361
Abstract
Alcohol intake and estrogen deficiency can both affect bone physiology and have shown to have an adverse effect on dental implant therapy. However, the combination of both factors on osseointegration is unknown. The aim of this study was to evaluate osseointegration in rats fed with alcohol and presenting induced estrogen deficiency. Ninety-six female rats were divided according to diet and hormonal condition into 6 groups as follows: group Sh-W: sham (simulated ovariectomy) control, food and water ad libitum; group Sh-Et: sham, food and 20% ethanol solution ad libitum; group Sh-Su: sham, food and sucrose solution controlled to ensure an isocaloric diet in relation to Sh-Et; group Ov-W: ovariectomy, food and water ad libitum; group Ov-Et: ovariectomy, food and 20% ethanol solution ad libitum; and group Ov-Su: ovariectomy, food and sucrose solution controlled to ensure an isocaloric diet as Ov-Et. The groups were subdivided according to time of euthanasia: 30 and 45 days after placement of implants. Implant surgery was performed 1 month after ovariectomy or sham. After euthanasia, the femurs were removed and evaluated by histomorphometry. Groups Ov-Et and Ov-Su showed the lowest percentage of bone-to-implant contact. The combination of alcohol intake and estrogen deficiency, and the combination of estrogen deficiency and reduced ingestion of food can negatively affect osseointegration in rats.
Details
- Title: Subtitle
- Negative effects of alcohol intake and estrogen deficiency combination on osseointegration in a rat model
- Creators
- Camila Porto de Deco - Department of Biosciences and Oral Diagnosis, São José dos Campos School of Dentistry, São Paulo State University, São Paulo, BrazilAdriana Mathias Pereira da Silva MarchiniMary Anne Moreira BárbaraLuana Marotta Reis de VasconcellosRosilene Fernandes da RochaLeonardo Marchini
- Resource Type
- Journal article
- Publication Details
- The Journal of oral implantology, Vol.37(6), pp.633-639
- Publisher
- United States
- DOI
- 10.1563/AAID-JOI-D-10-00048
- PMID
- 21504361
- ISSN
- 0160-6972
- eISSN
- 1548-1336
- Language
- English
- Date published
- 12/2011
- Academic Unit
- Preventive and Community Dentistry
- Record Identifier
- 9983997196902771
Metrics
31 Record Views