Journal article
Negishi coupling between alpha-alkyl(aryl)thio vinyl zinc chloride and alpha-bromo vinyl ether: a convergent synthesis of 2-alkoxy-3-alkyl(aryl)thiobuta-1,3-dienes
Organic letters, Vol.4(5), pp.691-694
03/07/2002
DOI: 10.1021/ol010252k
PMID: 11869103
Abstract
[reaction: see text] A convergent approach for the stereoselective synthesis of 2-alkoxy-3-alkyl(aryl)thiobuta-1,3-dienes has been developed. It was found that Negishi coupling between alpha-alkyl(aryl)thio vinyl zinc chloride and alpha-bromo vinyl ether or Negishi coupling between alpha-bromo vinyl sulfide and alpha-alkoxy vinyl zinc chloride provided the best yield and stereoselectivity.
Details
- Title: Subtitle
- Negishi coupling between alpha-alkyl(aryl)thio vinyl zinc chloride and alpha-bromo vinyl ether: a convergent synthesis of 2-alkoxy-3-alkyl(aryl)thiobuta-1,3-dienes
- Creators
- Mei Su - University of IowaYing Kang - University of IowaWensheng Yu - University of IowaZhengmao Hua - University of IowaZhendong Jin - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Organic letters, Vol.4(5), pp.691-694
- DOI
- 10.1021/ol010252k
- PMID
- 11869103
- ISSN
- 1523-7060
- eISSN
- 1523-7052
- Language
- English
- Date published
- 03/07/2002
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984365898702771
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