Journal article
Neighborhood-level Socioeconomic Position During Early Pregnancy and Risk of Gastroschisis
Epidemiology (Cambridge, Mass.), Vol.34(4), pp.576-588
07/01/2023
DOI: 10.1097/EDE.0000000000001621
PMCID: PMC10291502
PMID: 36976718
Abstract
Neighborhood-level socioeconomic position has been shown to influence birth outcomes, including selected birth defects. This study examines the un derstudied association between neighborhood-level socioeconomic position during early pregnancy and the risk of gastroschisis, an abdominal birth defect of increasing prevalence.
We conducted a case-control study of 1,269 gastroschisis cases and 10,217 controls using data from the National Birth Defects Prevention Study (1997-2011). To characterize neighborhood-level socioeconomic position, we conducted a principal component analysis to construct two indices-Neighborhood Deprivation Index (NDI) and Neighborhood Socioeconomic Position Index (nSEPI). We created neighborhood-level indices using census socioeconomic indicators corresponding to census tracts associated with addresses where mothers lived the longest during the periconceptional period. We used generalized estimating equations to estimate odds ratios (ORs) and 95% confidence intervals (CIs), with multiple imputations for missing data and adjustment for maternal race-ethnicity, household income, education, birth year, and duration of residence.
Mothers residing in moderate (NDI Tertile 2 aOR = 1.23; 95% CI = 1.03, 1.48 and nSEPI Tertile 2 aOR = 1.24; 95% CI = 1.04, 1.49) or low socioeconomic neighborhoods (NDI Tertile 3 aOR = 1.28; 95% CI = 1.05, 1.55 and nSEPI Tertile 3 aOR = 1.32, 95% CI = 1.09, 1.61) were more likely to deliver an infant with gastroschisis compared with mothers residing in high socioeconomic neighborhoods.
Our findings suggest that lower neighborhood-level socioeconomic position during early pregnancy is associated with elevated odds of gastroschisis. Additional epidemiologic studies may aid in confirming this finding and evaluating potential mechanisms linking neighborhood-level socioeconomic factors and gastroschisis.
Details
- Title: Subtitle
- Neighborhood-level Socioeconomic Position During Early Pregnancy and Risk of Gastroschisis
- Creators
- Dayna T Neo - University of North Carolina at Chapel HillTania A Desrosiers - University of North Carolina at Chapel HillChantel L Martin - University of North Carolina at Chapel HillSuzan L Carmichael - Stanford University School of MedicineMuge Gucsavas-Calikoglu - University of North Carolina at Chapel HillKristin M Conway - University of IowaShannon Pruitt Evans - Eagle Global Scientific LLC, San Antonio, TXMarcia L Feldkamp - University of UtahSuzanne M Gilboa - National Center on Birth Defects and Developmental DisabilitiesTabassum Z Insaf - University at Albany, State University of New YorkFadi I Musfee - University of Arkansas for Medical SciencesGary M Shaw - Stanford University School of MedicineCharles J Shumate - Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TXMartha M Werler - Boston UniversityAndrew F Olshan - University of North Carolina at Chapel HillNational Birth Defects Prevention Study
- Resource Type
- Journal article
- Publication Details
- Epidemiology (Cambridge, Mass.), Vol.34(4), pp.576-588
- DOI
- 10.1097/EDE.0000000000001621
- PMID
- 36976718
- PMCID
- PMC10291502
- NLM abbreviation
- Epidemiology
- ISSN
- 1044-3983
- eISSN
- 1531-5487
- Grant note
- P2C HD050924 / NICHD NIH HHS T32 HD052468 / NICHD NIH HHS P30 ES010126 / NIEHS NIH HHS U01 DD001227 / NCBDD CDC HHS
- Language
- English
- Date published
- 07/01/2023
- Academic Unit
- Epidemiology
- Record Identifier
- 9984627340202771
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