Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization

Ibrahim Zuniga-Chaves; Shoshannah Eggers; Ashley E. Kates; Nasia Safdar; Garret Suen; Kristen M. C. Malecki

doi:10.1038/s41522-023-00430-3

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Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization

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Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization

Ibrahim Zuniga-Chaves, Shoshannah Eggers, Ashley E. Kates, Nasia Safdar, Garret Suen and Kristen M. C. Malecki

NPJ biofilms and microbiomes, Vol.9(1), 61

08/28/2023

DOI: 10.1038/s41522-023-00430-3

PMCID: PMC10462741

PMID: 37640705

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Abstract

Social disparities continue to limit universal access to health care, directly impacting both lifespan and quality of life. Concomitantly, the gut microbiome has been associated with downstream health outcomes including the global rise in antibiotic resistance. However, limited evidence exists examining socioeconomic status (SES) associations with gut microbiome composition. To address this, we collected information on the community-level SES, gut microbiota, and other individual cofactors including colonization by multidrug-resistant organisms (MDROs) in an adult cohort from Wisconsin, USA. We found an association between SES and microbial composition that is mediated by food insecurity. Additionally, we observed a higher prevalence of MDROs isolated from individuals with low diversity microbiomes and low neighborhood SES. Our integrated population-based study considers how the interplay of several social and economic factors combine to influence gut microbial composition while providing a framework for developing future interventions to help mitigate the SES health gap.

Details

Title: Subtitle: Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization
Creators: Ibrahim Zuniga-Chaves - University of Wisconsin–Madison
Shoshannah Eggers - University of Iowa
Ashley E. Kates - University of Wisconsin–Madison
Nasia Safdar - University of Wisconsin–Madison
Garret Suen - University of Wisconsin–Madison
Kristen M. C. Malecki - Madison, WI USA IL Chicago, USA
Resource Type: Journal article
Publication Details: NPJ biofilms and microbiomes, Vol.9(1), 61
DOI: 10.1038/s41522-023-00430-3
PMID: 37640705
PMCID: PMC10462741
NLM abbreviation: NPJ Biofilms Microbiomes
eISSN: 2055-5008
Publisher: Nature Publishing Group UK
Grant note: 1U01AI125053-01A1; 1U01AI125053-01A1 / ; ;
Language: English
Date published: 08/28/2023
Academic Unit: Epidemiology; Injury Prevention Research Center
Record Identifier: 9984458060202771

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