Journal article
Neoadjuvant Chemoradiation Therapy Is Associated with Adverse Outcomes in Patients Undergoing Pancreaticoduodenectomy for Pancreatic Cancer
The American surgeon, Vol.85(11), pp.1276-1280
11/01/2019
DOI: 10.1177/000313481908501136
PMID: 31775971
Abstract
The use of neoadjuvant chemoradiation therapy in patients with pancreatic adenocarcinoma is emerg-ing as an acceptable therapy option. The effects of neoadjuvant therapy on 30 days' outcomes in patients with pancreatic cancer are not well defined in the literature. NSQIP (2009-2012) was used. Only patients with a diagnosis of pancreatic cancer and those who underwent a Whipple were included in the analysis. Patient who underwent neoadjuvant chemoradiation therapy were compared with those who did not receive therapy. Main outcome measures were as follows: complications, >= 2 units of blood transfusions, length of stay, readmission rates, return to the operating room, and 30-day mortality. A total of 1445 patients (395: neoadjuvant chemoradiation and 1050: no neoadjuvant therapy) were identified. The mean age was 67 +/- 12 years, and 51 per cent of the patients were male. Neoadjuvant chemoradiation therapy was associated with increase in readmission rates (18% vs 12.2%, P 0.02), unanticipated return to the operating room (2.3% vs 1.1%, P 0.03) with no difference in mortality rates. Neoadjuvant chemoradiation therapy is associated with increase in inhospital complications. These differences in outcomes may be explained by the more advance stage of pancreatic cancer in these subsets of patients. Resource utilization and preoperative rehabilitation are of utmost significance to overcome this rise in complications associated with neoadjuvant chemoradiation therapy.
Details
- Title: Subtitle
- Neoadjuvant Chemoradiation Therapy Is Associated with Adverse Outcomes in Patients Undergoing Pancreaticoduodenectomy for Pancreatic Cancer
- Creators
- Hassan Aziz - Keck Hospital of USCMuhammad Zeeshan - Westchester Medical CenterTun Jie - University of ArizonaFelipe B. Maegawa - Southern Arizona VA Health Care System
- Resource Type
- Journal article
- Publication Details
- The American surgeon, Vol.85(11), pp.1276-1280
- Publisher
- Southeastern Surgical Congress
- DOI
- 10.1177/000313481908501136
- PMID
- 31775971
- ISSN
- 0003-1348
- eISSN
- 1555-9823
- Number of pages
- 5
- Language
- English
- Date published
- 11/01/2019
- Academic Unit
- Surgery
- Record Identifier
- 9984701656102771
Metrics
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