Journal article
Neoadjuvant Radiotherapy-Related Wound Morbidity in Soft Tissue Sarcoma: Perspectives for Radioprotective Agents
Cancers, Vol.12(8), pp.1-26
08/01/2020
DOI: 10.3390/cancers12082258
PMCID: PMC7465163
PMID: 32806601
Abstract
Historically, patients with localized soft tissue sarcomas (STS) of the extremities would undergo limb amputation. It was subsequently determined that the addition of radiation therapy (RT) delivered prior to (neoadjuvant) or after (adjuvant) a limb-sparing surgical resection yielded equivalent survival outcomes to amputation in appropriate patients. Generally, neoadjuvant radiation offers decreased volume and dose of high-intensity radiation to normal tissue and increased chance of achieving negative surgical margins-but also increases wound healing complications when compared to adjuvant radiotherapy. This review elaborates on the current neoadjuvant/adjuvant RT approaches, wound healing complications in STS, and the potential application of novel radioprotective agents to minimize radiation-induced normal tissue toxicity.
Details
- Title: Subtitle
- Neoadjuvant Radiotherapy-Related Wound Morbidity in Soft Tissue Sarcoma: Perspectives for Radioprotective Agents
- Creators
- Cameron M Callaghan - University of Iowa Hospitals and ClinicsM. M Hasibuzzaman - University of IowaSamuel N Rodman - University of IowaJessica E Goetz - University of Iowa Hospitals and ClinicsKranti A Mapuskar - University of Iowa Hospitals and ClinicsMichael S Petronek - University of Iowa Hospitals and ClinicsEmily J Steinbach - University of Iowa Hospitals and ClinicsBenjamin J Miller - University of Iowa Hospitals and ClinicsCasey F Pulliam - University of IowaMitchell C Coleman - University of Iowa Hospitals and ClinicsVarun V Monga - University of Iowa Hospitals and ClinicsMohammed M Milhem - University of Iowa Hospitals and ClinicsDouglas R Spitz - University of Iowa Hospitals and ClinicsBryan G Allen - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Cancers, Vol.12(8), pp.1-26
- DOI
- 10.3390/cancers12082258
- PMID
- 32806601
- PMCID
- PMC7465163
- NLM abbreviation
- Cancers (Basel)
- ISSN
- 2072-6694
- eISSN
- 2072-6694
- Publisher
- MDPI
- Number of pages
- 26
- Grant note
- P30-CA086862 / Cancer Center Support Grant through the University of Iowa Holden Comprehensive Cancer Center Department of Radiation Oncology P01-CA217797 / National Institute of Health
- Language
- English
- Date published
- 08/01/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Nephrology, Dialysis and Transplantation; Hematology, Oncology, and Blood & Marrow Transplantation; Stead Family Department of Pediatrics; Pathology; Iowa Neuroscience Institute; Orthopedics and Rehabilitation; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984242417702771
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