Neonatal AVPR1a Methylation and In-Utero Exposure to Maternal Smoking

Nichole Nidey; Katherine Bowers; Lili Ding; Hong Ji; Robert T. Ammerman; Kimberly Yolton; E. Melinda Mahabee-Gittens; Alonzo T. Folger

doi:10.3390/toxics11100855

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Neonatal AVPR1a Methylation and In-Utero Exposure to Maternal Smoking

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Neonatal AVPR1a Methylation and In-Utero Exposure to Maternal Smoking

Nichole Nidey, Katherine Bowers, Lili Ding, Hong Ji, Robert T. Ammerman, Kimberly Yolton, E. Melinda Mahabee-Gittens and Alonzo T. Folger

Toxics (Basel), Vol.11(10), 855

10/13/2023

DOI: 10.3390/toxics11100855

PMCID: PMC10611161

PMID: 37888705

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Abstract

(1) Introduction: Epigenetic changes have been proposed as a biologic link between in-utero exposure to maternal smoking and health outcomes. Therefore, we examined if in-utero exposure to maternal smoking was associated with infant DNA methylation (DNAm) of cytosine-phosphate-guanine dinucleotides (CpG sites) in the arginine vasopressin receptor 1A AVPR1a gene. The AVPR1a gene encodes a receptor that interacts with the arginine vasopressin hormone and may influence physiological stress regulation, blood pressure, and child development. (2) Methods: Fifty-two infants were included in this cohort study. Multivariable linear models were used to examine the effect of in-utero exposure to maternal smoking on the mean DNAm of CpG sites located at AVPR1a. (3) Results: After adjusting the model for substance use, infants with in-utero exposure to maternal smoking had a reduction in DNAm at AVPR1a CpG sites by −0.02 (95% CI −0.03, −0.01) at one month of age. In conclusion, in-utero exposure to tobacco smoke can lead to differential patterns of DNAm of AVPR1a among infants. Conclusions: Future studies are needed to identify how gene expression in response to early environmental exposures contributes to health outcomes.

Details

Title: Subtitle: Neonatal AVPR1a Methylation and In-Utero Exposure to Maternal Smoking
Creators: Nichole Nidey - University of Iowa
Katherine Bowers - Cincinnati Children's Hospital Medical Center
Lili Ding - Cincinnati Children's Hospital Medical Center
Hong Ji - University of California, Davis
Robert T. Ammerman - Cincinnati Children's Hospital Medical Center
Kimberly Yolton - Cincinnati Children's Hospital Medical Center
E. Melinda Mahabee-Gittens
Alonzo T. Folger - Cincinnati Children's Hospital Medical Center
Resource Type: Journal article
Publication Details: Toxics (Basel), Vol.11(10), 855
DOI: 10.3390/toxics11100855
PMID: 37888705
PMCID: PMC10611161
NLM abbreviation: Toxics
ISSN: 2305-6304
eISSN: 2305-6304
Grant note: DOI: 10.13039/100000066, name: National Institute of Environmental Health Sciences, award: R01ES030743; name: the Cincinnati Children’s Hospital Medical Center Trustee Grant
Language: English
Date published: 10/13/2023
Academic Unit: Epidemiology; Addiction Medicine; Craniofacial Anomalies Research Center
Record Identifier: 9984479660102771

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