Neonatal Catch Up Growth Increases Diabetes Susceptibility But Improves Behavioral and Cardiovascular Outcomes of Low Birth Weight Male Mice

Gregory M HERMANN; Rachel L MILLER; Gwen E ERKONEN; Lindsay M DALLAS; Elise HSU; Vivian ZHU; Robert D ROGHAIR

doi:10.1203/PDR.0b013e3181a7c5fd

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Neonatal Catch Up Growth Increases Diabetes Susceptibility But Improves Behavioral and Cardiovascular Outcomes of Low Birth Weight Male Mice

Journal article

Open access

Peer reviewed

Neonatal Catch Up Growth Increases Diabetes Susceptibility But Improves Behavioral and Cardiovascular Outcomes of Low Birth Weight Male Mice

Gregory M HERMANN, Rachel L MILLER, Gwen E ERKONEN, Lindsay M DALLAS, Elise HSU, Vivian ZHU and Robert D ROGHAIR

Pediatric research, Vol.66(1), pp.53-58

2009

DOI: 10.1203/PDR.0b013e3181a7c5fd

PMCID: PMC2703479

PMID: 19342983

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Abstract

Premature infants are at increased risk for persistent growth failure, neurodevelopmental impairment, hypertension, and diabetes. Rapid neonatal growth has been linked to the increasing prevalence of diabetes and obesity. Nutritional goals for the premature infant with incipient growth failure have thus become a source of controversy. We used isogenic mice with natural variation in perinatal growth to test the hypothesis that neonatal catch up growth improves the neurobehavioral and cardiovascular outcomes of low-birth weight mice, despite an increase in diabetes susceptibility. Adult mice that experienced prenatal and neonatal growth restriction had persistent growth failure, hypertension, and neurobehavioral alterations. When switched from standard rodent chow to a hypercaloric diet, growth restricted mice were protected from diet-induced obesity. Among low-birth weight male mice, neonatal catch up growth normalized neurobehavioral and cardiovascular phenotypes, but led to insulin resistance and high fat diet-induced diabetes. Among low-birth weight female mice, neonatal catch up growth did not prevent the development of adult hypertension and significantly increased measures of anxiety, including self-injury and the avoidance of open spaces. These studies support the importance of the perinatal environment in the resetting of adult disease susceptibility and suggest an earlier window of vulnerability among growth restricted female mice.

Gynecology. Andrology. Obstetrics

General aspects

Diabetes. Impaired glucose tolerance

Diseases of mother, fetus and pregnancy

Biological and medical sciences

Endocrinopathies

Etiopathogenesis. Screening. Investigations. Target tissue resistance

Pregnancy. Fetus. Placenta

Medical sciences

Endocrine pancreas. Apud cells (diseases)

Details

Title: Subtitle: Neonatal Catch Up Growth Increases Diabetes Susceptibility But Improves Behavioral and Cardiovascular Outcomes of Low Birth Weight Male Mice
Creators: Gregory M HERMANN - Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, United States
Rachel L MILLER - Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, United States
Gwen E ERKONEN - Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, United States
Lindsay M DALLAS - Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, United States
Elise HSU - Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, United States
Vivian ZHU - Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, United States
Robert D ROGHAIR - Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, United States
Resource Type: Journal article
Publication Details: Pediatric research, Vol.66(1), pp.53-58
Publisher: Lippincott Williams & Wilkins
DOI: 10.1203/PDR.0b013e3181a7c5fd
PMID: 19342983
PMCID: PMC2703479
ISSN: 0031-3998
eISSN: 1530-0447
Language: English
Date published: 2009
Academic Unit: Stead Family Department of Pediatrics; Neonatology
Record Identifier: 9984093505802771

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