Neonatal Morbidities among Moderately Preterm Infants with and without Exposure to Antenatal Corticosteroids

Sanjay Chawla; Girija Natarajan; Dhuly Chowdhury; Abhik Das; Michele Walsh; Edward F. Bell; Abbot R. Laptook; Krisa Van Meurs; Carl T. D'Angio; Barbara J. Stoll; Sara B. DeMauro; Seetha Shankaran

doi:10.1055/s-0038-1642059

Back

Neonatal Morbidities among Moderately Preterm Infants with and without Exposure to Antenatal Corticosteroids

Journal article

Open access

Peer reviewed

Neonatal Morbidities among Moderately Preterm Infants with and without Exposure to Antenatal Corticosteroids

Sanjay Chawla, Girija Natarajan, Dhuly Chowdhury, Abhik Das, Michele Walsh, Edward F. Bell, Abbot R. Laptook, Krisa Van Meurs, Carl T. D'Angio, Barbara J. Stoll, …

American journal of perinatology, Vol.35(12), pp.1213-1221

10/2018

DOI: 10.1055/s-0038-1642059

PMCID: PMC6156933

PMID: 29702710

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/6156933View

Open Access

Abstract

Abstract Objective We aimed to compare the rates of “surfactant treated respiratory disease” and other neonatal morbidities among moderately preterm (MPT) infants exposed to no, partial, or a complete course of antenatal corticosteroids (ANS). Study Design This observational cohort study evaluated MPT infants (29 0/7 –33 6/7 weeks' gestational age), born between January 2012 and November 2013 and enrolled in the “MPT Registry” of the National Institute of Child Health and Human Development Neonatal Research Network. Results Data were available for 5,886 infants, including 676 with no exposure, 1225 with partial, and 3,985 with a complete course of ANS. Among no, partial, and complete ANS groups, respectively, there were significant differences in rates of delivery room resuscitation (4.1, 1.4, and 1.2%), surfactant-treated respiratory disease (26.5, 26.3, and 20%), and severe intracranial hemorrhage (3, 2, and 0.8%). Complete ANS course was associated with lower surfactant-treated respiratory disease, compared with partial ANS (odds ratio [OR] 0.62; 95% confidence interval [CI] 0.52–0.74), and no ANS groups (OR 0.52; 95% CI 0.41–0.66) on adjusted analysis. Conclusion In MPT infants, ANS exposure is associated with lower delivery room resuscitation, surfactant-treated respiratory disease, and severe intracranial hemorrhage; with the lowest frequency of morbidities associated with a complete course.

Original Article

Details

Title: Subtitle: Neonatal Morbidities among Moderately Preterm Infants with and without Exposure to Antenatal Corticosteroids
Creators: Sanjay Chawla - Hutzel Women's Hospital
Girija Natarajan - Hutzel Women's Hospital
Dhuly Chowdhury - RTI International
Abhik Das - RTI International
Michele Walsh - Case Western Reserve University
Edward F. Bell - University of Iowa
Abbot R. Laptook - Women & Infants Hospital of Rhode Island
Krisa Van Meurs - Stanford University
Carl T. D'Angio - University of Rochester
Barbara J. Stoll - The University of Texas Health Science Center
Sara B. DeMauro - Children's Hospital of Philadelphia
Seetha Shankaran - Hutzel Women's Hospital
Resource Type: Journal article
Publication Details: American journal of perinatology, Vol.35(12), pp.1213-1221
DOI: 10.1055/s-0038-1642059
PMID: 29702710
PMCID: PMC6156933
NLM abbreviation: Am J Perinatol
ISSN: 0735-1631
eISSN: 1098-8785
Publisher: Thieme Medical Publishers
Language: English
Date published: 10/2018
Academic Unit: Stead Family Department of Pediatrics; Neonatology
Record Identifier: 9984353832302771

Metrics

7 Record Views

5 Times Cited - Web of Science

See more details