Journal article
Neonatal Outcomes of Extremely Preterm Infants From the NICHD Neonatal Research Network
Pediatrics (Evanston), Vol.126(3), pp.443-456
09/2010
DOI: 10.1542/peds.2009-2959
PMCID: PMC2982806
PMID: 20732945
Abstract
OBJECTIVE: This report presents data from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network on care of and morbidity and mortality rates for very low birth weight infants, according to gestational age (GA).
METHODS: Perinatal/neonatal data were collected for 9575 infants of extremely low GA (22–28 weeks) and very low birth weight (401–1500 g) who were born at network centers between January 1, 2003, and December 31, 2007.
RESULTS: Rates of survival to discharge increased with increasing GA (6% at 22 weeks and 92% at 28 weeks); 1060 infants died at ≤12 hours, with most early deaths occurring at 22 and 23 weeks (85% and 43%, respectively). Rates of prenatal steroid use (13% and 53%, respectively), cesarean section (7% and 24%, respectively), and delivery room intubation (19% and 68%, respectively) increased markedly between 22 and 23 weeks. Infants at the lowest GAs were at greatest risk for morbidities. Overall, 93% had respiratory distress syndrome, 46% patent ductus arteriosus, 16% severe intraventricular hemorrhage, 11% necrotizing enterocolitis, and 36% late-onset sepsis. The new severity-based definition of bronchopulmonary dysplasia classified more infants as having bronchopulmonary dysplasia than did the traditional definition of supplemental oxygen use at 36 weeks (68%, compared with 42%). More than one-half of infants with extremely low GAs had undetermined retinopathy status at the time of discharge. Center differences in management and outcomes were identified.
Details
- Title: Subtitle
- Neonatal Outcomes of Extremely Preterm Infants From the NICHD Neonatal Research Network
- Creators
- Barbara J Stoll - Department of Pediatrics, School of Medicine, Emory University, Children’s Healthcare of Atlanta, Atlanta, GeorgiaNellie I Hansen - Statistics and Epidemiology Unit, RTI International, Research Triangle Park, North CarolinaEdward F Bell - Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IowaSeetha Shankaran - Department of Pediatrics, School of Medicine, Wayne State University, Detroit, MichiganAbbot R Laptook - Department of Pediatrics, Women and Infants’ Hospital, Brown University, Providence, Rhode IslandMichele C Walsh - Department of Pediatrics, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, OhioEllen C Hale - Department of Pediatrics, School of Medicine, Emory University, Children’s Healthcare of Atlanta, Atlanta, GeorgiaNancy S Newman - Department of Pediatrics, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, OhioKurt Schibler - Department of Pediatrics, School of Medicine, University of Cincinnati, Cincinnati, OhioWaldemar A Carlo - Division of Neonatology, School of Medicine, University of Alabama at Birmingham, Birmingham, AlabamaKathleen A Kennedy - Department of Pediatrics, University of Texas Medical School at Houston, Houston, TexasBrenda B Poindexter - Department of Pediatrics, School of Medicine, Indiana University, Indianapolis, IndianaNeil N Finer - Department of Neonatology, University of California, San Diego, Medical Center, San Diego, CaliforniaRichard A Ehrenkranz - Department of Pediatrics, School of Medicine, Yale University, New Haven, ConnecticutShahnaz Duara - Department of Pediatrics, Miller School of Medicine, University of Miami, Miami, FloridaPablo J Sánchez - Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TexasT. Michael O’Shea - Department of Pediatrics, School of Medicine, Wake Forest University, Winston-Salem, North CarolinaRonald N Goldberg - Department of Pediatrics, School of Medicine, Duke University, Durham, North CarolinaKrisa P Van Meurs - Department of Pediatrics, School of Medicine, Stanford University Palo Alto, CaliforniaRoger G Faix - Division of Neonatology, Department of Pediatrics, School of Medicine, University of Utah, Salt Lake City, UtahDale L Phelps - Department of Pediatrics, School of Medicine and Dentistry, University of Rochester, Rochester, New YorkIvan D Frantz - Division of Newborn Medicine, Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, MassachusettsKristi L Watterberg - Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, New MexicoShampa Saha - Statistics and Epidemiology Unit, RTI International, Research Triangle Park, North CarolinaAbhik Das - Statistics and Epidemiology Unit, RTI International, Rockville, MarylandRosemary D Higgins - Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health Bethesda, MarylandEunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
- Resource Type
- Journal article
- Publication Details
- Pediatrics (Evanston), Vol.126(3), pp.443-456
- DOI
- 10.1542/peds.2009-2959
- PMID
- 20732945
- PMCID
- PMC2982806
- NLM abbreviation
- Pediatrics
- ISSN
- 0031-4005
- eISSN
- 1098-4275
- Publisher
- American Academy of Pediatrics
- Language
- English
- Date published
- 09/2010
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984093471802771
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