Journal article
Neonatal Risk Factors for Pulmonary Vein Stenosis in Infants Born Preterm with Severe Bronchopulmonary Dysplasia
The Journal of pediatrics, Vol.275, 114252
08/22/2024
DOI: 10.1016/j.jpeds.2024.114252
PMID: 39181320
Abstract
To evaluate associations between neonatal risk factors and pulmonary vein stenosis (PVS) among infants born preterm with severe bronchopulmonary dysplasia (sBPD).
We performed a case-control study of infants born from 2010 to 2022 at < 32 weeks’ gestation with sBPD among 46 neonatal intensive care units in the Children’s Hospitals Neonatal Consortium. Cases with PVS were matched to controls using epoch of diagnosis (2010-2016; 2017-2022) and hospital. Multivariable logistic regression analyses were utilized to evaluate PVS association with neonatal risk factors.
From 10,171 preterm infants with sBPD, we identified 109 cases with PVS and matched those to 327 controls. The prevalence of PVS (1.07%) rose between epochs (0.8% in 2010-2016 to 1.2% in 2017-2022). Relative to controls, infants with PVS were more likely to be <500 grams at birth, to be small for gestational age <10th%ile (SGA), or have surgical necrotizing enterocolitis (NEC), atrial septal defects (ASD), or pulmonary hypertension (PH). In multivariable models, these associations persisted, and SGA, surgical NEC, ASD, and PH were each independently associated with PVS. Among infants on respiratory support at 36 weeks’ postmenstrual age, infants with PVS had 4.3-fold higher odds of receiving mechanical ventilation at 36 weeks’ postmenstrual age. Infants with PVS also had 3.6-fold higher odds of in-hospital mortality relative to controls.
In a large cohort of preterm infants with sBPD, multiple independent, neonatal risk factors are associated with PVS. These results lay important groundwork for the development of targeted screening to guide the diagnosis and management of PVS in preterm infants with sBPD.
Details
- Title: Subtitle
- Neonatal Risk Factors for Pulmonary Vein Stenosis in Infants Born Preterm with Severe Bronchopulmonary Dysplasia
- Creators
- Erica McArthur - Children's Healthcare of AtlantaKarna Murthy - Lurie Children's HospitalIsabella Zaniletti - Children’s Minnesota - St. Paul HospitalMegha Sharma - Arkansas Children's HospitalJoanne Lagatta - Children's Hospital of WisconsinMolly Ball - The Ohio State University Wexner Medical CenterNicolas Porta - Lurie Children's HospitalTheresa Grover - Children's Hospital ColoradoPhilip Levy - Harvard UniversityMichael Padula - Children's Hospital of PhiladelphiaShannon Hamrick - Emory University School of MedicineShilpa Vyas-Read - Emory University School of MedicineAnthony Piazza - Children's Healthcare of AtlantaGregory Sysyn - Children's Healthcare of AtlantaAshley Lucke - Dell Children's Medical Center of Central TexasMolly Pont - Dell Children's Medical Center of Central TexasAllison Black - Children's of AlabamaCarl Coghill - Children's of AlabamaAnne Hansen - Boston Children's HospitalEugenia Pallotto - Levine Children's HospitalGustave Falciglia - Lurie Children's HospitalBeth Haberman - Cincinnati Children's Hospital Medical CenterTetyana Nesterenko - Cleveland ClinicThomas Bartman - Nationwide Children's HospitalSushmita Yallapragada - Children's Medical CenterLina Chalak - Children's Medical CenterDanielle Smith - Children's Hospital ColoradoStephanie Bourque - Children's Hospital ColoradoGirija Natarjan - Children's Hospital of MichiganAnnie Chi - Cook Children's Health Care SystemYvette Johnson - Cook Children's Health Care SystemAnnmarie Gotiolo - Connecticut Children's Medical CenterLakshmi Katarkan - Texas Children's HospitalKristina Reber - Texas Children's HospitalRebecca Rose - Riley Children's FoundationJulie Lindower - University of IowaJulie Weiner - Children's Mercy HospitalLaura Carroll - Arkansas Children's HospitalRachel Chapman - Children's Hospital of Los AngelesNina Menda - University of Wisconsin American Family Children's HospitalMark Weems - Le Bonheur Children's HospitalAnn Downey - Children's MinnesotaPriscilla Joe - UCSF Benioff Children's HospitalTrent Tipple - Children's Hospital of OklahomaPatricia Williams - Children's Hospital of OklahomaNicole Birge - Children's Hospital & Medical CenterMichel Mikhael - Children's Hospital of Orange CountyNarendra Dereddy - AdventHealth for ChildrenRajan Wadhawan - AdventHealth for ChildrenAaron Weiss - Nemours Children's ClinicMichael Padula - Children's Hospital of PhiladelphiaVilarmis Quinones - St. Christopher's Hospital for ChildrenPam Griffiths - Phoenix Children's HospitalToby Yanowitz - Children's Hospital of PittsburghEllen Bendel-Stenzel - Mayo ClinicCon Yee Ling - Primary Children's HospitalMark Speziale - Rady Children's Hospital-San DiegoRobert DiGeronimo - Seattle Children's HospitalElizabeth Jacobsen - Seattle Children's HospitalBeverly Brozanski - St. Louis Children's HospitalRakesh Rao - St. Louis Children's HospitalLinda Van Marter - Johns Hopkins All Children's HospitalKyong-Soon Lee - Hospital for Sick ChildrenBillie Lou Short - Children's NationalKevin Sullivan - Dupont HospitalCherrie Welch - Brenner Children's HospitalCHNC Severe BPD and Cardiology Focus Groups
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.275, 114252
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.jpeds.2024.114252
- PMID
- 39181320
- ISSN
- 0022-3476
- eISSN
- 1097-6833
- Language
- English
- Electronic publication date
- 08/22/2024
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984699247902771
Metrics
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