Journal article
Neonatal alloimmune thrombocytopenia associated with maternal-fetal incompatibility for blood group B
Transfusion (Philadelphia, Pa.), Vol.48(2), pp.358-364
02/2008
DOI: 10.1111/j.1537-2995.2007.01531.x
PMCID: PMC3572505
PMID: 18028270
Abstract
Blood group A and B antigens are expressed only weakly on platelets (PLTs) of most individuals but are very strongly expressed on PLTs from approximately 1 percent of normal subjects (Type II high expressers). The implications of this trait for transfusion medicine are undefined. A family was studied in which two Group B infants were born with neonatal thrombocytopenia, whereas a third infant whose blood group was A(2) had a normal PLT count at birth. Serologic studies demonstrated a maternal antibody that reacted strongly with PLTs from the father and the two group B children in flow cytometry and with GPIIb/IIIa from their PLTs in solid-phase assays. No PLT-specific antibodies were detected in maternal serum sample, but it contained a high-titer immunoglobulin G antibody specific for blood group B. All PLT-reactive antibody in the mother's serum was removed by absorption with pooled, washed group A and B red cells (RBCs). Studies with monoclonal anti-B and measurement of serum B-glycosyltransferase activity showed that the father and both group B children were Type II high expressers of blood group B. The findings indicate that high-titer blood group antibodies acquired from the mother can cause thrombocytopenia in infants possessing the Type II high-expresser phenotype despite competition for antibody binding by blood group antigens expressed on RBCs and other tissues.
Details
- Title: Subtitle
- Neonatal alloimmune thrombocytopenia associated with maternal-fetal incompatibility for blood group B
- Creators
- Brian R Curtis - Platelet & Neutrophil Immunology Laboratory, BloodCenter of Wisconsin, Milwaukee, WI 53201-2178, USA. brian.curtis@bcw.eduAndrea FickAndrew J LochowiczJanice G McFarlandRobert H BallJulie PetersonRichard H Aster
- Resource Type
- Journal article
- Publication Details
- Transfusion (Philadelphia, Pa.), Vol.48(2), pp.358-364
- Publisher
- United States
- DOI
- 10.1111/j.1537-2995.2007.01531.x
- PMID
- 18028270
- PMCID
- PMC3572505
- ISSN
- 0041-1132
- eISSN
- 1537-2995
- Grant note
- R01 HL013629 / NHLBI NIH HHS R56 HL013629 / NHLBI NIH HHS HL-13629 / NHLBI NIH HHS R37 HL013629 / NHLBI NIH HHS
- Language
- English
- Date published
- 02/2008
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9983931874702771
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