Neonatal complex arrhythmias possibly related to a TTN mutation

William N Evans; Ruben J Acherman; Ian H Law; Nicholas H Von Bergen; Ricardo A Samson; Humberto Restrepo

doi:10.3233/NPM-16120

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Neonatal complex arrhythmias possibly related to a TTN mutation

Journal article

Peer reviewed

Neonatal complex arrhythmias possibly related to a TTN mutation

William N Evans, Ruben J Acherman, Ian H Law, Nicholas H Von Bergen, Ricardo A Samson and Humberto Restrepo

Journal of neonatal-perinatal medicine, Vol.10(3), pp.343-346

2017

DOI: 10.3233/NPM-16120

PMID: 28854511

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Abstract

We describe a neonate born with complex arrhythmias that included concurrent atrial and ventricular tachycardias. Genetic testing demonstrated a mutation in the TTN gene, which codes for titin, a large protein found in striated muscle sarcomeres. The complex arrhythmias were successfully treated with amiodarone and flecainide. The patient remains asymptomatic with normal biventricular function. We speculate that the complex arrhythmias and TTN gene mutation may be related.

Tachycardia, Supraventricular - drug therapy

Tachycardia, Supraventricular - genetics

Tachycardia, Ventricular - drug therapy

Humans

Connectin - genetics

Anti-Arrhythmia Agents - therapeutic use

Bundle-Branch Block - diagnosis

Bundle-Branch Block - genetics

Bundle-Branch Block - drug therapy

Tachycardia, Supraventricular - diagnosis

Amiodarone - therapeutic use

Infant, Premature

Tachycardia, Ventricular - diagnosis

Electrocardiography

Tachycardia, Ventricular - genetics

Mutation

Infant, Newborn

Fetal Monitoring

Flecainide - therapeutic use

Details

Title: Subtitle: Neonatal complex arrhythmias possibly related to a TTN mutation
Creators: William N Evans - Department of Pediatrics, Division of Cardiology, University of Nevada, Reno School of Medicine, Las Vegas, NV, USA
Ruben J Acherman - Department of Pediatrics, Division of Cardiology, University of Nevada, Reno School of Medicine, Las Vegas, NV, USA
Ian H Law - Department of Pediatrics, Division of Cardiology, University of Iowa Carver College of Medicine, Iowa City, USA
Nicholas H Von Bergen - Department of Pediatrics, Division of Cardiology, University of Wisconsin-Madison, Madison, WI, USA
Ricardo A Samson - Department of Pediatrics, Division of Cardiology, University of Nevada, Reno School of Medicine, Las Vegas, NV, USA
Humberto Restrepo - Department of Pediatrics, Division of Cardiology, University of Nevada, Reno School of Medicine, Las Vegas, NV, USA
Resource Type: Journal article
Publication Details: Journal of neonatal-perinatal medicine, Vol.10(3), pp.343-346
DOI: 10.3233/NPM-16120
PMID: 28854511
ISSN: 1934-5798
eISSN: 1878-4429
Language: English
Date published: 2017
Academic Unit: Cardiology; Stead Family Department of Pediatrics
Record Identifier: 9984093363402771

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