Journal article
Neonatal lupus erythematosus, a clinical case
Andes pediatrica : revista Chilena de pediatría, Vol.94(2), pp.240-245
04/2023
DOI: 10.32641/andespediatr.v94i2.3889
PMID: 37358118
Abstract
Neonatal lupus erythematosus (NLE) is a very rare autoimmune disease, occurring in neonates born to mothers who present auto-antibodies to cytoplasmic antigens of Sjogren's syndrome. In most ca-ses, the clinical course is benign toward spontaneous resolution, but there is a group of patients who develop severe involvement of the cardiac conduction system, therefore, early detection is critical. Objective: To describe a clinical case of neonatal lupus erythematosus emphasizing the importance of timely diagnosis in the patient and the mother. Clinical Case: A 33-year-old woman, with a his -tory of hypertension, came to the dermatology department for her 15-day-old male neonate who presented a recent onset of round, erythematous, raised-edged, and non-scaling plaques consistent with NLE. Cardiac conduction involvement was ruled out. Newborn's laboratory tests showed mo-derate neutropenia, mild increase of transaminases, and positive anti-Ro and anti-La antibodies. On directed anamnesis, the mother reported a personal history of symptoms consistent with connective tissue disease, such as fatigue, alopecia, and xerophthalmia. Antinuclear antibodies from the mother showed titers of 1/1280 in a speckled pattern, positive anti-double-stranded DNA antibodies, and anti-Ro and Anti-La antibodies. Schirmer Test was consistent with dry eye, therefore, Systemic Lupus Erythematosus associated with Sjogren's Syndrome was diagnosed. The infant was followed up for 5 months with remission of cutaneous manifestations and normalization of laboratory tests. Con-clusion: Although cutaneous manifestations of NLE are benign and transient in the newborn, these can be associated with other life-threatening manifestations that require an active search and prompt management by the medical team. A 25% of mothers of newborns with NLE are asymptomatic or unaware of their SLE diagnosis before delivery, so timely diagnosis of NLE leads to the diagnosis of asymptomatic mothers, improving their follow-up and treatment.
Details
- Title: Subtitle
- Neonatal lupus erythematosus, a clinical case
- Creators
- Catalina Montane - Serv Salud Coquimbo, Coquimbo, ChileLia Hojman - Clínica AlemanaTrinidad Hasbun - Univ Desarrollo Santiago, Fac Med, Serv Dermatol, Clin Alemana Santiago, Santiago, Chile
- Resource Type
- Journal article
- Publication Details
- Andes pediatrica : revista Chilena de pediatría, Vol.94(2), pp.240-245
- DOI
- 10.32641/andespediatr.v94i2.3889
- PMID
- 37358118
- NLM abbreviation
- Andes Pediatr
- ISSN
- 2452-6053
- eISSN
- 2452-6053
- Publisher
- Soc Chilena Pediatria
- Number of pages
- 6
- Language
- English; Spanish
- Date published
- 04/2023
- Academic Unit
- Dermatology
- Record Identifier
- 9984966748302771
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