Journal article
Neonatal medial prefrontal lesions and recovery of spatial delayed alternation in the Rat: Effects of delay interval
Developmental psychobiology, Vol.28(5), pp.269-279
07/1995
DOI: 10.1002/dev.420280503
PMID: 7672459
Abstract
We have previously shown that rats given medial prefrontal lesions on postnatal Day 10 show a performance deficit on spatial delayed alternation (2‐s delay) when tested between Days 19 and 23, but show recovery of function by Days 27–33 (Freeman & Stanton, 1992). The present study attempted to (a) examine the effects of extending the delay interval from 2 s to 15 or 45 s on the ontogeny of spatial delayed alternation; and (b) determine whether these longer delays would alter the ontogenetic profile of recovery from medial prefrontal damage. Animals were given medial prefrontal lesions (mPFC) or sham surgery on Day 10. They received acquisition training on delayed alternation with a 2‐s delay on Day 21 or Day 28, followed by “probe” tests at delays of 15 and 45 s on the following day (Day 22 or Day 29). On Days 21–22 there was an overall effect of lesion at the 2‐, 15‐, and 45‐s delay intervals indicating and early deficit. However, on Days 28–29 there was no effect of lesion at the end of acquisition or at the 15‐ or 45‐s delay intervals. Recovery of memory function by mPFC animals on this task appears to occur during the weanling period regardless of delay interval. © 1995 Johnv Wiley & Sons, Inc.
Details
- Title: Subtitle
- Neonatal medial prefrontal lesions and recovery of spatial delayed alternation in the Rat: Effects of delay interval
- Creators
- Christy S CarterJohn H FreemanMark E Stanton
- Resource Type
- Journal article
- Publication Details
- Developmental psychobiology, Vol.28(5), pp.269-279
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company; Hoboken
- DOI
- 10.1002/dev.420280503
- PMID
- 7672459
- ISSN
- 0012-1630
- eISSN
- 1098-2302
- Number of pages
- 11
- Language
- English
- Date published
- 07/1995
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984065861902771
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