Journal article
Neonatal outcomes of moderately preterm infants compared to extremely preterm infants
Pediatric research, Vol.82(2), pp.297-304
08/01/2017
DOI: 10.1038/pr.2017.46
PMCID: PMC5552426
PMID: 28419085
Abstract
BACKGROUND: Extremely preterm infants (EPT, <29 weeks' gestation) represent only 0.9% of births in the United States; yet these infants are the focus of most published research. Moderately preterm neonates (MPT, 29-33(6/7) weeks) are an understudied group of high-risk infants.
METHODS: To determine the neonatal outcomes of MPT infants across the gestational age spectrum, and to compare these with EPT infants. A prospective observational cohort was formed in 18 level 3-4 neonatal intensive care units (NICUs) in the Eunice Kennedy Shriver NICHD Neonatal Research Network. Participants included all MPT infants admitted to NICUs and all EPT infants born at sites between January 2012 and November 2013. Antenatal characteristics and neonatal morbidities were abstracted from records using pre-specified definitions by trained neonatal research nurses.
RESULTS: MPT infants experienced morbidities similar to, although at lower rates than, those of EPT infants. The main cause of mortality was congenital malformation, accounting for 43% of deaths. Central Nervous System injury occurred, including intraventricular hemorrhage. Most MPT infants required respiratory support, but sequelae such as bronchopulmonary dysplasia were rare. The primary contributors to hospitalization beyond 36 weeks' gestation were inability to achieve adequate oral intake and persistent apnea.
CONCLUSIONS: MPT infants experience morbidity and prolonged hospitalization. Such morbidity deserves focused research to improve therapeutic and prevention strategies.
Details
- Title: Subtitle
- Neonatal outcomes of moderately preterm infants compared to extremely preterm infants
- Creators
- Michele C. Walsh - Case Western Reserve UniversityEdward F. Bell - University of IowaSarah Kandefer - Environmental Protection AgencyShampa Saha - Environmental Protection AgencyWaldemar A. Carlo - University of Alabama at BirminghamCarl T. D'angio - University of RochesterAbbot R. Laptook - Brown UniversityPablo J. Sanchez - Nationwide Children's HospitalBarbara J. Stoll - Emory UniversitySeetha Shankaran - Wayne State UniversityKrisa P. Van Meurs - Stanford UniversityNoah Cook - University of PennsylvaniaRosemary D. Higgins - National Institutes of HealthAbhik Das - Environmental Protection AgencyNancy S. Newman - Case Western Reserve UniversityKurt Schibler - Cincinnati Children's Hospital Medical CenterBarbara Schmidt - University of PennsylvaniaC. Michael Cotten - Duke UniversityBrenda B. Poindexter - Cincinnati Children's Hospital Medical CenterKristi L. Watterberg - University of New MexicoWilliam E. Truog - Children's Mercy HospitalEunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
- Resource Type
- Journal article
- Publication Details
- Pediatric research, Vol.82(2), pp.297-304
- Publisher
- Springer Nature
- DOI
- 10.1038/pr.2017.46
- PMID
- 28419085
- PMCID
- PMC5552426
- ISSN
- 0031-3998
- eISSN
- 1530-0447
- Number of pages
- 8
- Grant note
- National Institutes of Health, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) UG1HD068263 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) National Institutes of Health, the National Center for Advancing Translational Sciences
- Language
- English
- Date published
- 08/01/2017
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984354008402771
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