Neonates with cystic fibrosis have a reduced nasal liquid pH; A small pilot study

Mahmoud H Abou Alaiwa; Alison M Beer; Alejandro A Pezzulo; Janice L Launspach; Rebecca A Horan; David A Stoltz; Timothy D Starner; Michael J Welsh; Joseph Zabner

doi:10.1016/j.jcf.2013.12.006

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Neonates with cystic fibrosis have a reduced nasal liquid pH; A small pilot study

Journal article

Peer reviewed

Neonates with cystic fibrosis have a reduced nasal liquid pH; A small pilot study

Mahmoud H Abou Alaiwa, Alison M Beer, Alejandro A Pezzulo, Janice L Launspach, Rebecca A Horan, David A Stoltz, Timothy D Starner, Michael J Welsh and Joseph Zabner

Journal of cystic fibrosis, Vol.13(4), pp.373-377

07/2014

DOI: 10.1016/j.jcf.2013.12.006

PMCID: PMC4060428

PMID: 24418186

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Abstract

Disrupted HCO3– transport and reduced airway surface liquid (ASL) pH in cystic fibrosis (CF) may initiate airway disease. We hypothesized that ASL pH is reduced in neonates with CF. In neonates with and without CF, we measured pH of nasal ASL. We also measured nasal pH in older children and adults. In neonates with CF, nasal ASL (pH5.2±0.3) was more acidic than in non-CF neonates (pH6.4±0.2). In contrast, nasal pH of CF children and adults was similar to values measured in people without CF. At an age when infection, inflammation and airway wall remodeling are minimal, neonates with CF had an acidic nasal ASL compared to babies without CF. The CF:non-CF pH difference disappeared in older individuals, perhaps because secondary manifestations of disease increase ASL pH. These results aid understanding of CF pathogenesis and suggest opportunities for therapeutic intervention and monitoring of disease.

Neonatal screen

Neonates

Cystic fibrosis

Airway surface liquid (ASL)

Details

Title: Subtitle: Neonates with cystic fibrosis have a reduced nasal liquid pH; A small pilot study
Creators: Mahmoud H Abou Alaiwa - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Alison M Beer - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Alejandro A Pezzulo - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Janice L Launspach - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Rebecca A Horan - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
David A Stoltz - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Timothy D Starner - Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Michael J Welsh - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Joseph Zabner - Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: Journal of cystic fibrosis, Vol.13(4), pp.373-377
DOI: 10.1016/j.jcf.2013.12.006
PMID: 24418186
PMCID: PMC4060428
NLM abbreviation: J Cyst Fibros
ISSN: 1569-1993
eISSN: 1873-5010
Publisher: Elsevier BV
Grant note: name: Cystic Fibrosis Foundation Research Development Program, award: R458; name: Program Project Grant, award: HL51670
Language: English
Date published: 07/2014
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Iowa Neuroscience Institute; Neurosurgery; Internal Medicine
Record Identifier: 9984020796102771

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