Journal article
Nephrotoxic medications and acute kidney injury risk factors in the neonatal intensive care unit: clinical challenges for neonatologists and nephrologists
Pediatric nephrology (Berlin, West), Vol.35(11), pp.2077-2088
11/01/2020
DOI: 10.1007/s00467-019-04350-3
PMID: 31605211
Abstract
Neonatal acute kidney injury (AKI) is common. Critically ill neonates are at risk for AKI for many reasons including the severity of their underlying illnesses, prematurity, and nephrotoxic medications. In this educational review, we highlight four clinical scenarios in which both the illness itself and the medications indicated for their treatment are risk factors for AKI: sepsis, perinatal asphyxia, patent ductus arteriosus, and necrotizing enterocolitis. We review the available evidence regarding medications commonly used in the neonatal period with known nephrotoxic potential, including gentamicin, acyclovir, indomethacin, vancomycin, piperacillin-tazobactam, and amphotericin. We aim to illustrate the complexity of decision-making involved for both neonatologists and pediatric nephrologists when managing infants with these conditions and advocate for ongoing multidisciplinary collaboration in the development of better AKI surveillance protocols and AKI mitigation strategies to improve care for these vulnerable patients.
Details
- Title: Subtitle
- Nephrotoxic medications and acute kidney injury risk factors in the neonatal intensive care unit: clinical challenges for neonatologists and nephrologists
- Creators
- Heidi J. Murphy - Medical University of South CarolinaBrady Thomas - University of IowaBrynna Van Wyk - University of IowaSarah B. Tierney - University of IowaDavid T. Selewski - Medical University of South CarolinaJennifer G. Jetton - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Pediatric nephrology (Berlin, West), Vol.35(11), pp.2077-2088
- Publisher
- Springer Nature
- DOI
- 10.1007/s00467-019-04350-3
- PMID
- 31605211
- ISSN
- 0931-041X
- eISSN
- 1432-198X
- Number of pages
- 12
- Language
- English
- Date published
- 11/01/2020
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984353949702771
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