Journal article
Network Localization of Pediatric Lesion-Induced Dystonia
Annals of neurology, Vol.98(1), pp.152-162
07/2025
DOI: 10.1002/ana.27224
PMCID: PMC12176519
PMID: 40059836
Abstract
Dystonia is a movement disorder defined by involuntary muscle contractions leading to abnormal postures or twisting and repetitive movements. Classically dystonia has been thought of as a disorder of the basal ganglia, but newer results in idiopathic dystonia and lesion-induced dystonia in adults point to broader motor network dysfunction spanning the basal ganglia, cerebellum, premotor cortex, sensorimotor, and frontoparietal regions. It is unclear whether a similar network is shared between different etiologies of pediatric lesion-induced dystonia.
Three cohorts of pediatric patients with lesion-induced dystonia were identified. The lesion etiologies included hypoxia, kernicterus, and stroke versus comparison subjects with acquired lesions not associated with dystonia. Multivariate lesion-symptom mapping and lesion network mapping were used to evaluate the anatomy and networks associated with dystonia.
Multivariate lesion-symptom mapping showed that lesions of the putamen and globus pallidus were associated with dystonia (r = 0.41, p < 0.001). Lesion network mapping using normative connectome data from healthy children demonstrated that these regional findings occurred within a common brain-wide network that involves the basal ganglia, anterior and medial cerebellum, and cortical regions that overlap the cingulo-opercular action-mode and somato-cognitive-action networks.
We interpret these findings as novel evidence for a unified dystonia brain network that involves the somato-cognitive-action network, which is implicated in the coordination of movement. Elucidation of this network gives insight into the functional origins of dystonia and provides novel targets to investigate for therapeutic intervention. ANN NEUROL 2025.
Details
- Title: Subtitle
- Network Localization of Pediatric Lesion-Induced Dystonia
- Creators
- Rose Gelineau-Morel - Children's Mercy HospitalNomazulu Dlamini - University of TorontoJoel Bruss - University of IowaAlexander L Cohen - Boston Children's HospitalAmanda Robertson - Hospital for Sick ChildrenDimitrios Alexopoulos - Washington University in St. LouisChristopher D Smyser - Washington University in St. LouisAaron D Boes - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Annals of neurology, Vol.98(1), pp.152-162
- DOI
- 10.1002/ana.27224
- PMID
- 40059836
- PMCID
- PMC12176519
- NLM abbreviation
- Ann Neurol
- ISSN
- 1531-8249
- eISSN
- 1531-8249
- Publisher
- WILEY
- Grant note
- The Auxilium Foundation Simons Foundation Autism Research Initiative 3R01NS114405 / NINDS NIH HHS T32HD069038 / National Institute of Child Health and Human Development P50 HD103525 / NICHD NIH HHS K23MH120510 / NIMH NIH HHS
- Language
- English
- Electronic publication date
- 03/10/2025
- Date published
- 07/2025
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984799690702771
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