Networking in the nucleus: a spotlight on LEM-domain proteins

Lacy J Barton; Alexey A Soshnev; Pamela K Geyer

doi:10.1016/j.ceb.2015.03.005

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Networking in the nucleus: a spotlight on LEM-domain proteins

Journal article

Open access

Peer reviewed

Networking in the nucleus: a spotlight on LEM-domain proteins

Lacy J Barton, Alexey A Soshnev and Pamela K Geyer

Current opinion in cell biology, Vol.34, pp.1-8

06/2015

DOI: 10.1016/j.ceb.2015.03.005

PMCID: PMC4522374

PMID: 25863918

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https://www.ncbi.nlm.nih.gov/pmc/articles/4522374View

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Abstract

Proteins resident in the inner nuclear membrane and underlying nuclear lamina form a network that regulates nuclear functions. This review highlights a prominent family of nuclear lamina proteins that carries the LAP2-emerin-MAN1-domain (LEM-D). LEM-D proteins share an ability to bind lamins and tether repressive chromatin at the nuclear periphery. The importance of this family is underscored by findings that loss of individual LEM-D proteins causes progressive, tissue-restricted diseases, known as laminopathies. Diverse functions of LEM-D proteins are linked to interactions with unique and overlapping partners including signal transduction effectors, transcription factors and architectural proteins. Recent investigations suggest that LEM-D proteins form hubs within the nuclear lamina that integrate external signals important for tissue homeostasis and maintenance of progenitor cell populations.

Details

Title: Subtitle: Networking in the nucleus: a spotlight on LEM-domain proteins
Creators: Lacy J Barton - Department of Biochemistry, University of Iowa, College of Medicine, Iowa City, IA 52242, USA
Alexey A Soshnev - Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY, 10065, USA
Pamela K Geyer - Department of Biochemistry, University of Iowa, College of Medicine, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: Current opinion in cell biology, Vol.34, pp.1-8
DOI: 10.1016/j.ceb.2015.03.005
PMID: 25863918
PMCID: PMC4522374
NLM abbreviation: Curr Opin Cell Biol
ISSN: 0955-0674
eISSN: 1879-0410
Publisher: Elsevier Ltd
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: GM087341; DOI: 10.13039/100000011, name: HHMI; DOI: 10.13039/100001021, name: Damon Runyon Cancer Research Foundation, award: DRG-2185-14
Language: English
Date published: 06/2015
Academic Unit: Obstetrics and Gynecology; Biochemistry and Molecular Biology
Record Identifier: 9984025258502771

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