Journal article
Neural Circuits Underlying Reciprocal Cardiometabolic Crosstalk: 2023 Arthur C. Corcoran Memorial Lecture
Hypertension (Dallas, Tex. 1979), Vol.81(6), pp.1233-1243
03/27/2024
DOI: 10.1161/HYPERTENSIONAHA.124.22066
PMCID: PMC11096079
PMID: 38533662
Abstract
The interplay of various body systems, encompassing those that govern cardiovascular and metabolic functions, has evolved alongside the development of multicellular organisms. This evolutionary process is essential for the coordination and maintenance of homeostasis and overall health by facilitating the adaptation of the organism to internal and external cues. Disruption of these complex interactions contributes to the development and progression of pathologies that involve multiple organs. Obesity-associated cardiovascular risks, such as hypertension, highlight the significant influence that metabolic processes exert on the cardiovascular system. This cardiometabolic communication is reciprocal, as indicated by substantial evidence pointing to the ability of the cardiovascular system to affect metabolic processes, with pathophysiological implications in disease conditions. In this review, I outline the bidirectional nature of the cardiometabolic interaction, with special emphasis on the impact that metabolic organs have on the cardiovascular system. I also discuss the contribution of the neural circuits and autonomic nervous system in mediating the crosstalk between cardiovascular and metabolic functions in health and disease, along with the molecular mechanisms involved.
Details
- Title: Subtitle
- Neural Circuits Underlying Reciprocal Cardiometabolic Crosstalk: 2023 Arthur C. Corcoran Memorial Lecture
- Creators
- Kamal Rahmouni - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.81(6), pp.1233-1243
- DOI
- 10.1161/HYPERTENSIONAHA.124.22066
- PMID
- 38533662
- PMCID
- PMC11096079
- NLM abbreviation
- Hypertension
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Grant note
- National Institutes of Health: HL162773 Department of Veterans Affairs: BX004249, BX006040
K. Rahmouni is supported by the National Institutes of Health (HL162773), the Department of Veterans Affairs (BX004249 and BX006040), and the University of Iowa Fraternal Order of Eagles Diabetes Research Center.
- Language
- English
- Electronic publication date
- 03/27/2024
- Academic Unit
- Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984580316202771
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