Journal article
Neural Correlates of Vocal Production and Motor Control in Human Heschl's Gyrus
The Journal of neuroscience, Vol.36(7), pp.2302-2315
02/17/2016
DOI: 10.1523/JNEUROSCI.3305-14.2016
PMCID: PMC4756159
PMID: 26888939
Abstract
The present study investigated how pitch frequency, a perceptually relevant aspect of periodicity in natural human vocalizations, is encoded in Heschl's gyrus (HG), and how this information may be used to influence vocal pitch motor control. We recorded local field potentials from multicontact depth electrodes implanted in HG of 14 neurosurgical epilepsy patients as they vocalized vowel sounds and received brief (200 ms) pitch perturbations at 100 Cents in their auditory feedback. Event-related band power responses to vocalizations showed sustained frequency following responses that tracked voice fundamental frequency (F0) and were significantly enhanced in posteromedial HG during speaking compared with when subjects listened to the playback of their own voice. In addition to frequency following responses, a transient response component within the high gamma frequency band (75-150 Hz) was identified. When this response followed the onset of vocalization, the magnitude of the response was the same for the speaking and playback conditions. In contrast, when this response followed a pitch shift, its magnitude was significantly enhanced during speaking compared with playback. We also observed that, in anterolateral HG, the power of high gamma responses to pitch shifts correlated with the magnitude of compensatory vocal responses. These findings demonstrate a functional parcellation of HG with neural activity that encodes pitch in natural human voice, distinguishes between self-generated and passively heard vocalizations, detects discrepancies between the intended and heard vocalization, and contains information about the resulting behavioral vocal compensations in response to auditory feedback pitch perturbations.
The present study is a significant contribution to our understanding of sensor-motor mechanisms of vocal production and motor control. The findings demonstrate distinct functional parcellation of core and noncore areas within human auditory cortex on Heschl's gyrus that process natural human vocalizations and pitch perturbations in the auditory feedback. In addition, our data provide evidence for distinct roles of high gamma neural oscillations and frequency following responses for processing periodicity in human vocalizations during vocal production and motor control.
Details
- Title: Subtitle
- Neural Correlates of Vocal Production and Motor Control in Human Heschl's Gyrus
- Creators
- Roozbeh Behroozmand - Human Brain Research Laboratory, Department of Neurosurgery, University of Iowa, Iowa City, Iowa 52242, Speech Neuroscience Laboratory, Department of Communication Sciences and Disorders, University of South Carolina, Columbia, South Carolina 29208, r-behroozmand@sc.eduHiroyuki Oya - Human Brain Research Laboratory, Department of Neurosurgery, University of Iowa, Iowa City, Iowa 52242Kirill V Nourski - Human Brain Research Laboratory, Department of Neurosurgery, University of Iowa, Iowa City, Iowa 52242Hiroto Kawasaki - Human Brain Research Laboratory, Department of Neurosurgery, University of Iowa, Iowa City, Iowa 52242Charles R Larson - Speech Physiology Laboratory, Department of Communication Sciences and Disorders, Northwestern University, Evanston, Illinois 60208, andJohn F Brugge - Human Brain Research Laboratory, Department of Neurosurgery, University of Iowa, Iowa City, Iowa 52242, Department of Psychology, University of Wisconsin, Madison, Wisconsin 53705Matthew A Howard III - Human Brain Research Laboratory, Department of Neurosurgery, University of Iowa, Iowa City, Iowa 52242Jeremy D W Greenlee - Human Brain Research Laboratory, Department of Neurosurgery, University of Iowa, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.36(7), pp.2302-2315
- Publisher
- United States
- DOI
- 10.1523/JNEUROSCI.3305-14.2016
- PMID
- 26888939
- PMCID
- PMC4756159
- ISSN
- 0270-6474
- eISSN
- 1529-2401
- Grant note
- R01 DC004290 / NIDCD NIH HHS R01DC04290 / NIDCD NIH HHS K23 DC009589 / NIDCD NIH HHS K23DC009589 / NIDCD NIH HHS
- Language
- English
- Date published
- 02/17/2016
- Academic Unit
- Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
- Record Identifier
- 9984020506202771
Metrics
28 Record Views