Journal article
Neural Tube Defects and Maternal Folate Intake Among Pregnancies Conceived After Folic Acid Fortification in the United States
American journal of epidemiology, Vol.169(1), pp.9-17
2009
DOI: 10.1093/aje/kwn331
PMCID: PMC3139973
PMID: 18953063
Abstract
Rates of neural tube defects have decreased since folic acid fortification of the food supply in the United States. The authors’ objective was to evaluate the associations between neural tube defects and maternal folic acid intake among pregnancies conceived after fortification. This is a multicenter, case-control study that uses data from the National Birth Defects Prevention Study, 1998–2003. Logistic regression was used to compute crude and adjusted odds ratios between cases and controls assessing maternal periconceptional use of folic acid and intake of dietary folic acid. Among 180 anencephalic cases, 385 spina bifida cases, and 3, 963 controls, 21.1%, 25.2%, and 26.1%, respectively, reported periconceptional use of folic acid supplements. Periconceptional supplement use did not reduce the risk of having a pregnancy affected by a neural tube defect. Maternal intake of dietary folate was not significantly associated with neural tube defects. In this study conducted among pregnancies conceived after mandatory folic acid fortification, the authors found little evidence of an association between neural tube defects and maternal folic acid intake. A possible explanation is that folic acid fortification reduced the occurrence of folic acid-sensitive neural tube defects. Further investigation is warranted to possibly identify women who remain at increased risk of preventable neural tube defects.
Details
- Title: Subtitle
- Neural Tube Defects and Maternal Folate Intake Among Pregnancies Conceived After Folic Acid Fortification in the United States
- Creators
- Bridget S Mosley - Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital Research Institute, Little Rock, Arkansas, United StatesMario A Cleves - Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital Research Institute, Little Rock, Arkansas, United StatesAnna Maria SIEGA-RIZ - Departments of Epidemiology and Nutrition, University of North Carolina School of Public Health, Chapel Hill, North Carolina, United StatesGary M Shaw - March of Dimes Foundation, California Research Division, Oakland, California, United StatesMark A Canfield - Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, Texas, United StatesD Kim Waller - School of Public Health, University of Texas Houston Science Center, Houston, Texas, United StatesMartha M Werler - Slone Epidemiology Center at Boston University, Boston, Massachusetts, United StatesCharlotte A Hobbs - Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital Research Institute, Little Rock, Arkansas, United StatesNational Birth Defects Prevention Study
- Contributors
- Paul A Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- American journal of epidemiology, Vol.169(1), pp.9-17
- Publisher
- Oxford University Press
- DOI
- 10.1093/aje/kwn331
- PMID
- 18953063
- PMCID
- PMC3139973
- ISSN
- 0002-9262
- eISSN
- 1476-6256
- Language
- English
- Date published
- 2009
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984214848402771
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