Journal article
Neural basis of novel and well-learned recognition memory in schizophrenia: a positron emission tomography study
Human brain mapping, Vol.12(4), pp.219-231
04/2001
DOI: 10.1002/1097-0193(200104)12:4<219::aid-hbm1017>3.0.co;2-l
PMCID: PMC6871838
PMID: 11241873
Abstract
The level of familiarity of a given stimulus plays an important role in memory processing. Indeed, the novelty/familiarity of learned material has been proven to affect the pattern of activations during recognition memory tasks. We used visually presented words to investigate the neural basis of recognition memory for relatively novel and familiar stimuli in schizophrenia. Subjects were 34 healthy volunteers and 19 schizophrenia spectrum patients. Two experimental cognitive conditions were used: 1 week and again 1 day prior to the PET imaging subjects had to thoroughly learn a list of 18 words (well-learned memory). Subjects were also asked to learn another set of 18 words presented 1 min before the PET experiment (novel memory). During the PET session, subjects had to recognize the list of 18 words among 22 new (distractor) words. Subjects also performed a control task (reading words). A nonparametric randomization test and a statistical t-mapping method were used to determine between- and within-group differences. In patients the recognition of novel material produced relatively less flow in several frontal areas, superior temporal gyrus, insular cortex, and parahippocampal areas, and relatively higher activity in parietal areas, visual cortex, and cerebellum, compared to controls. No significant differences in flow were seen when comparing well-learned memory activations between groups. These results suggest that different neural pathways are engaged during novel recognition memory in patients with schizophrenia compared to healthy individuals. During recognition of novel material, patients failed to activate frontal/limbic regions, recruiting a set of posterior perceptual brain regions instead.
Details
- Title: Subtitle
- Neural basis of novel and well-learned recognition memory in schizophrenia: a positron emission tomography study
- Creators
- Benedicto Crespo-Facorro - Mental Health-Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USAAnne K WiserNancy C AndreasenDaniel S O'LearyG Leonard WatkinsLaura L Boles PontoRichard D Hichwa
- Resource Type
- Journal article
- Publication Details
- Human brain mapping, Vol.12(4), pp.219-231
- DOI
- 10.1002/1097-0193(200104)12:4<219::aid-hbm1017>3.0.co;2-l
- PMID
- 11241873
- PMCID
- PMC6871838
- NLM abbreviation
- Hum Brain Mapp
- ISSN
- 1065-9471
- eISSN
- 1097-0193
- Publisher
- United States
- Grant note
- MH31593 / NIMH NIH HHS MH40856 / NIMH NIH HHS MHCRC43271 / NIMH NIH HHS
- Language
- English
- Date published
- 04/2001
- Academic Unit
- Radiology; Psychiatry; Research Administration; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Physics and Astronomy; Radiation Oncology
- Record Identifier
- 9984003918002771
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