Neural changes in acute arthritis in monkeys. I. Parallel enhancement of responses of spinothalamic tract neurons to mechanical stimulation and excitatory amino acids

P M Dougherty; K A Sluka; L S Sorkin; K N Westlund; W D Willis

doi:10.1016/0165-0173(92)90002-4

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Journal article

Neural changes in acute arthritis in monkeys. I. Parallel enhancement of responses of spinothalamic tract neurons to mechanical stimulation and excitatory amino acids

P M Dougherty, K A Sluka, L S Sorkin, K N Westlund and W D Willis

Brain research. Brain research reviews, Vol.17(1), p.1

01/1992

DOI: 10.1016/0165-0173(92)90002-4

PMID: 1638273

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Abstract

Somatosensory neurons of the spinal cord, including projection neurons, become hyperexcitable to mechanical stimuli during the development of experimental arthritis in rats and cats and hence are suggested to participate in the generation of arthritic hyperalgesia in humans. The experiments described here show a potentiation of the responses of spinothalamic tract (STT) neurons in monkeys during the development of an acute arthritis. The results demonstrate that the responses of STT neurons to mechanical stimuli and to iontophoretically applied excitatory amino acids (EAAs), particularly those acting at non-N-methyl-D-aspartate (non-NMDA) receptors, become enhanced during the development of inflammation produced by intra-articular injection of kaolin and carrageenan. Since the enhancement of both responses follows a similar time course, the results of this work suggest a role for EAAs in the hyperalgesia associated with arthritis and hence may provide a possible pharmacologic target for alleviation and/or prevention of arthritic pain.

Acute Disease

Arthritis - physiopathology

Electric Stimulation

Neural Pathways - drug effects

Spinal Cord - drug effects

Macaca fascicularis

Neural Pathways - physiology

Thalamus - drug effects

Amino Acids - pharmacology

Arthritis - chemically induced

Iontophoresis

Biomechanical Phenomena

Animals

Thalamus - physiopathology

Afferent Pathways - physiology

Thalamus - cytology

Afferent Pathways - drug effects

Spinal Cord - physiopathology

Spinal Cord - cytology

Details

Title: Subtitle: Neural changes in acute arthritis in monkeys. I. Parallel enhancement of responses of spinothalamic tract neurons to mechanical stimulation and excitatory amino acids
Creators: P M Dougherty - Marine Biomedical Institute, University of Texas Medical Branch, Galveston 77550-2772
K A Sluka
L S Sorkin
K N Westlund
W D Willis
Resource Type: Journal article
Publication Details: Brain research. Brain research reviews, Vol.17(1), p.1
Publisher: Netherlands
DOI: 10.1016/0165-0173(92)90002-4
PMID: 1638273
ISSN: 0165-0173
eISSN: 1872-6321
Grant note: NS11255 / NINDS NIH HHS NS01445 / NINDS NIH HHS NS09743 / NINDS NIH HHS
Language: English
Date published: 01/1992
Academic Unit: Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
Record Identifier: 9984040208102771

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