Journal article
Neural changes in acute arthritis in monkeys. III : Changes in substance P, calcitonin gene-related peptide and glutamate in the dorsal horn of the spinal cord
Brain research reviews, Vol.17(1), pp.29-38
1992
DOI: 10.1016/0165-0173(92)90004-6
Abstract
The effects of an experimentally induced arthritis on immunoreactivity of putative primary afferents neurotransmitter/neuromodulators were examined. Immunoreactive staining for substance P (SP), calcitonin generelated peptide (CGRP) and glutamate (Glu) in the monkey dorsal horn was examined following inflammation of one knee joint induced by injection of 5% kaolin and 5% carrageenan. Spinal cords were examined at different time periods after induction of arthritis (2.5, 4, 6 and 8 h). Side to side differences in immunoreactivity were determined by a computer assisted quantitation system. A significant overall decrease in immunoreactivity of the lumbar versus the cervical dorsal horn was found for SP. The decrease for SP showed maximal changes of 68.3% at 4 h and 54.7% at 6 h. Immunoreactivity for CGRP was decreased 31.5% at 8 h and variable at other time points. Immunoreactivity for Glu, showed an ipsilateral increase of 31.4% at 4 h, 33.7% at 6 h, 39.9% at 8 h and a significant effect for lumbar versus cervical. Repetitive peripheral stimulation of the joint was shown to be important for changes in SP and Glu immunoreactivity. Without frequent peripheral stimulation in the early stages of the development of arthritis, SP showed no quantitative side to side differences. Increases in Glu immunoreactivity were present but not as prominent with minimal joint manipulation. These studies suggest that Glu may be involved in the aching pain of inflammation at rest whereas SP, CGRP and Glu may mediate pain induced by joint movement.
Details
- Title: Subtitle
- Neural changes in acute arthritis in monkeys. III : Changes in substance P, calcitonin gene-related peptide and glutamate in the dorsal horn of the spinal cord
- Creators
- K. A SLUKA - Univ. Texas medical branch, marine biomedical inst., dep. anatomy neurosci., Galveston TX 77550-2772, United StatesP. M DOUGHERTY - Univ. Texas medical branch, marine biomedical inst., dep. anatomy neurosci., Galveston TX 77550-2772, United StatesL. S SORKIN - Univ. Texas medical branch, marine biomedical inst., dep. anatomy neurosci., Galveston TX 77550-2772, United StatesW. D WILLIS - Univ. Texas medical branch, marine biomedical inst., dep. anatomy neurosci., Galveston TX 77550-2772, United StatesK. N WESTLUND - Univ. Texas medical branch, marine biomedical inst., dep. anatomy neurosci., Galveston TX 77550-2772, United States
- Resource Type
- Journal article
- Publication Details
- Brain research reviews, Vol.17(1), pp.29-38
- Publisher
- Elsevier; Amsterdam
- DOI
- 10.1016/0165-0173(92)90004-6
- ISSN
- 0165-0173
- eISSN
- 1872-6321
- Language
- English
- Date published
- 1992
- Academic Unit
- Nursing; Neuroscience and Pharmacology; Physical Therapy and Rehabilitation Science; Iowa Neuroscience Institute
- Record Identifier
- 9984072069302771
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