Journal article
Neural circuitry and plasticity mechanisms underlying delay eyeblink conditioning
Learning & memory (Cold Spring Harbor, N.Y.), Vol.18(10), pp.666-677
10/2011
DOI: 10.1101/lm.2023011
PMCID: PMC3861981
PMID: 21969489
Abstract
Pavlovian eyeblink conditioning has been used extensively as a model system for examining the neural mechanisms underlying associative learning. Delay eyeblink conditioning depends on the intermediate cerebellum ipsilateral to the conditioned eye. Evidence favors a two-site plasticity model within the cerebellum with long-term depression of parallel fiber synapses on Purkinje cells and long-term potentiation of mossy fiber synapses on neurons in the anterior interpositus nucleus. Conditioned stimulus and unconditioned stimulus inputs arise from the pontine nuclei and inferior olive, respectively, converging in the cerebellar cortex and deep nuclei. Projections from subcortical sensory nuclei to the pontine nuclei that are necessary for eyeblink conditioning are beginning to be identified, and recent studies indicate that there are dynamic interactions between sensory thalamic nuclei and the cerebellum during eyeblink conditioning. Cerebellar output is projected to the magnocellular red nucleus and then to the motor nuclei that generate the blink response(s). Tremendous progress has been made toward determining the neural mechanisms of delay eyeblink conditioning but there are still significant gaps in our understanding of the necessary neural circuitry and plasticity mechanisms underlying cerebellar learning.
Details
- Title: Subtitle
- Neural circuitry and plasticity mechanisms underlying delay eyeblink conditioning
- Creators
- John H Freeman - Department of Psychology and Neuroscience Program, The University of Iowa, Iowa City, Iowa 52242, USAAdam B Steinmetz - Department of Psychology and Neuroscience Program, The University of Iowa, Iowa City, Iowa 52242, USA
- Resource Type
- Journal article
- Publication Details
- Learning & memory (Cold Spring Harbor, N.Y.), Vol.18(10), pp.666-677
- Publisher
- Cold Spring Harbor Laboratory Press
- DOI
- 10.1101/lm.2023011
- PMID
- 21969489
- PMCID
- PMC3861981
- ISSN
- 1072-0502
- eISSN
- 1549-5485
- Alternative title
- Neural mechanisms underlying eyeblink conditioning
- Language
- English
- Date published
- 10/2011
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984065755302771
Metrics
18 Record Views