Journal article
Neural correlates of cognitive decline in ALS: An fNIRS study of the prefrontal cortex
Cognitive neuroscience, Vol.4(2), pp.115-121
01/01/2013
DOI: 10.1080/17588928.2013.797889
PMCID: PMC4727749
PMID: 24073736
Abstract
Functional near infrared spectroscopy (fNIRS) is a clinically feasible functional neuroimaging modality for detecting early cortical changes due to neurodegenerative diseases that affect cognition. The objective of this preliminary investigation was to test for reduced prefrontal activity in persons with cognitive impairments due to amyotrophic lateral sclerosis (ALS). Participants were required to complete two N-back working memory tasks of increasing complexity during fNIRS recordings. Five participants with ALS and age- and gender-matched healthy participants comprised the experimental and control groups, respectively. Significant reductions in prefrontal oxygenation levels were observed for the left and right hemispheres in the ALS group compared to the control group. Reduced prefrontal activation despite intact behavioral performance for a working memory task may suggest early neuroanatomical, neurophysiological and/or compensatory mechanisms in affected individuals. The fNIRS-derived oxygenation measure shows promise as a sensitive neural marker to identify early neuropsychological impairments due to ALS.
Details
- Title: Subtitle
- Neural correlates of cognitive decline in ALS: An fNIRS study of the prefrontal cortex
- Creators
- Mili S. Kuruvilla - Nebraska Medical CenterJordan R. Green - Harvard University PressHasan Ayaz - Drexel UniversityDaniel L. Murman - Nebraska Hematology-Oncology
- Resource Type
- Journal article
- Publication Details
- Cognitive neuroscience, Vol.4(2), pp.115-121
- DOI
- 10.1080/17588928.2013.797889
- PMID
- 24073736
- PMCID
- PMC4727749
- NLM abbreviation
- Cogn Neurosci
- ISSN
- 1758-8928
- eISSN
- 1758-8936
- Publisher
- Taylor & Francis
- Number of pages
- 7
- Grant note
- R01 DC009890 / NIH-NIDCD; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Deafness & Other Communication Disorders (NIDCD) R01DC009890 / NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Deafness & Other Communication Disorders (NIDCD) Barkley Trust Munroe Meyer Institute of Genetics and Rehabilitation
- Language
- English
- Date published
- 01/01/2013
- Academic Unit
- Communication Sciences and Disorders
- Record Identifier
- 9984446440002771
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