Neural correlates of formal thought disorder: An activation likelihood estimation meta-analysis

Tobias Wensing; Edna C Cieslik; Veronika I Müller; Felix Hoffstaedter; Simon B Eickhoff; Thomas Nickl-Jockschat

doi:10.1002/hbm.23706

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Neural correlates of formal thought disorder: An activation likelihood estimation meta-analysis

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Neural correlates of formal thought disorder: An activation likelihood estimation meta-analysis

Tobias Wensing, Edna C Cieslik, Veronika I Müller, Felix Hoffstaedter, Simon B Eickhoff and Thomas Nickl-Jockschat

Human brain mapping, Vol.38(10), pp.4946-4965

10/2017

DOI: 10.1002/hbm.23706

PMCID: PMC5685170

PMID: 28653797

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Abstract

Formal thought disorder (FTD) refers to a psychopathological dimension characterized by disorganized and incoherent speech. Whether symptoms of FTD arise from aberrant processing in language-related regions or more general cognitive networks, however, remains debated. Here, we addressed this question by a quantitative meta-analysis of published functional neuroimaging studies on FTD. The revised Activation Likelihood Estimation (ALE) algorithm was used to test for convergent aberrant activation changes in 18 studies (30 experiments) investigating FTD, of which 17 studies comprised schizophrenia patients and one study healthy subjects administered to S-ketamine. Additionally, we analyzed task-dependent and task-independent (resting-state) functional connectivity (FC) of brain regions showing convergence in activation changes. Subsequent functional characterization was performed for the initial clusters and the delineated connectivity networks by reference to the BrainMap database. Consistent activation changes were found in the left superior temporal gyrus (STG) and two regions within the left posterior middle temporal gyrus (p-MTG), ventrally (vp-MTG) and dorsally (dp-MTG). Functional characterization revealed a prominent functional association of ensuing clusters from our ALE meta-analysis with language and speech processing, as well as auditory perception in STG and with social cognition in dp-MTG. FC analysis identified task-dependent and task-independent networks for all three seed regions, which were mainly related to language and speech processing, but showed additional involvement in higher order cognitive functions. Our findings suggest that FTD is mainly characterized by abnormal activation in brain regions of the left hemisphere that are associated with language and speech processing, but also extend to higher order cognitive functions. Hum Brain Mapp 38:4946-4965, 2017. © 2017 Wiley Periodicals, Inc.

Neuroimaging

Brain - diagnostic imaging

Likelihood Functions

Language Disorders - diagnostic imaging

Brain - physiopathology

Humans

Mental Disorders - diagnostic imaging

Language Disorders - physiopathology

Mental Disorders - physiopathology

Details

Title: Subtitle: Neural correlates of formal thought disorder: An activation likelihood estimation meta-analysis
Creators: Tobias Wensing - JARA Translational Brain Medicine, Aachen, Germany
Edna C Cieslik - Institute for Systems Neuroscience, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany
Veronika I Müller - Institute for Systems Neuroscience, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany
Felix Hoffstaedter - Institute for Systems Neuroscience, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany
Simon B Eickhoff - Institute for Systems Neuroscience, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany
Thomas Nickl-Jockschat - JARA Translational Brain Medicine, Aachen, Germany
Resource Type: Journal article
Publication Details: Human brain mapping, Vol.38(10), pp.4946-4965
DOI: 10.1002/hbm.23706
PMID: 28653797
PMCID: PMC5685170
NLM abbreviation: Hum Brain Mapp
ISSN: 1097-0193
eISSN: 1097-0193
Publisher: United States
Grant note: R01 MH074457 / NIMH NIH HHS
Language: English
Date published: 10/2017
Academic Unit: Psychiatry; Neuroscience and Pharmacology
Record Identifier: 9984003982102771

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