Neural fate of seen and unseen faces in visuospatial neglect: A combined event-related functional MRI and event-related potential study

Patrik Vuilleumier; Noam Sagiv; Eliot Hazeltine; Russel A Poldrack; Diane Swick; Robert D Rafal; John D. E Gabrieli

doi:10.1073/pnas.051436898

Back

Neural fate of seen and unseen faces in visuospatial neglect: A combined event-related functional MRI and event-related potential study

Journal article

Open access

Peer reviewed

Neural fate of seen and unseen faces in visuospatial neglect: A combined event-related functional MRI and event-related potential study

Patrik Vuilleumier, Noam Sagiv, Eliot Hazeltine, Russel A Poldrack, Diane Swick, Robert D Rafal and John D. E Gabrieli

Proceedings of the National Academy of Sciences - PNAS, Vol.98(6), pp.3495-3500

03/13/2001

DOI: 10.1073/pnas.051436898

PMCID: PMC30681

PMID: 11248106

Files and links (1)

url

https://doi.org/10.1073/pnas.051436898View

Published (Version of record) Open Access

Abstract

To compare neural activity produced by visual events that escape or reach conscious awareness, we used event-related MRI and evoked potentials in a patient who had neglect and extinction after focal right parietal damage, but intact visual fields. This neurological disorder entails a loss of awareness for stimuli in the field contralateral to a brain lesion when stimuli are simultaneously presented on the ipsilateral side, even though early visual areas may be intact, and single contralateral stimuli may still be perceived. Functional MRI and event-related potential study were performed during a task where faces or shapes appeared in the right, left, or both fields. Unilateral stimuli produced normal responses in V1 and extrastriate areas. In bilateral events, left faces that were not perceived still activated right V1 and inferior temporal cortex and evoked nonsignificantly reduced N1 potentials, with preserved face-specific negative potentials at 170 ms. When left faces were perceived, the same stimuli produced greater activity in a distributed network of areas including right V1 and cuneus, bilateral fusiform gyri, and left parietal cortex. Also, effective connectivity between visual, parietal, and frontal areas increased during perception of faces. These results suggest that activity can occur in V1 and ventral temporal cortex without awareness, whereas coupling with dorsal parietal and frontal areas may be critical for such activity to afford conscious perception.

Biological Sciences

Details

Title: Subtitle: Neural fate of seen and unseen faces in visuospatial neglect: A combined event-related functional MRI and event-related potential study
Creators: Patrik Vuilleumier - Department of Neurology, University of California, Davis, CA 95616
Noam Sagiv - Department of Neurology, University of California, Davis, CA 95616
Eliot Hazeltine - Department of Neurology, University of California, Davis, CA 95616
Russel A Poldrack - Department of Neurology, University of California, Davis, CA 95616
Diane Swick - Department of Neurology, University of California, Davis, CA 95616
Robert D Rafal - Department of Neurology, University of California, Davis, CA 95616
John D. E Gabrieli - Department of Neurology, University of California, Davis, CA 95616
Resource Type: Journal article
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.98(6), pp.3495-3500
DOI: 10.1073/pnas.051436898
PMID: 11248106
PMCID: PMC30681
NLM abbreviation: Proc Natl Acad Sci U S A
ISSN: 0027-8424
eISSN: 1091-6490
Publisher: National Academy of Sciences
Language: English
Date published: 03/13/2001
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984070415302771

Metrics

18 Record Views

163 Times Cited - Web of Science