Neural input modulates osmotically stimulated release of vasopressin into the supraoptic nucleus

Mike Ludwig; Michael F Callahan; Rainer Landgraf; Alan Kim Johnson; Mariana Morris

doi:10.1152/ajpendo.1996.270.5.e787

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Neural input modulates osmotically stimulated release of vasopressin into the supraoptic nucleus

Journal article

Peer reviewed

Neural input modulates osmotically stimulated release of vasopressin into the supraoptic nucleus

Mike Ludwig, Michael F Callahan, Rainer Landgraf, Alan Kim Johnson and Mariana Morris

The American journal of physiology, Vol.270(5 Pt 1), pp.E787-792

05/1996

DOI: 10.1152/ajpendo.1996.270.5.e787

PMID: 8967466

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Abstract

The effects of lesioning of the anteroventral third ventricle (AV3V) region on vasopressin (VP) release into the supraoptic nucleus (SON) and blood in response to central and systemic osmotic stimulation were determined. Microdialysis probes were implanted bilaterally within the SON of male urethan-anesthetized rats with sham or AV3V lesions. Osmotic stimuli were administered intraperitoneally (3.5 M NaCl, 600 microliters/100 g body wt) and then via the microdialysis probes (1 M NaCl-artificial cerebrospinal fluid). AV3V lesions attenuated the response to systemic osmotic stimulation. The lesioned rats showed no increase in intranuclear VP release and reduced plasma VP (increase of 42.6 +/- 8.4 vs. 78.0 +/- 16.4 pg/ml) and blood pressure responses (7.1 +/- 2.3 vs. 19.6 +/- 3.2 mmHg) to intraperitoneal NaCl. In contrast, the endocrine and cardiovascular responses to direct osmotic stimulation of the nucleus were as seen in previous studies and seemed to be unaffected by the lesion. These results show that lesion of the AV3V region interrupts neuronal inputs which trigger VP secretion from the posterior pituitary as well as release into the extracellular compartment of the SON.

Analysis of Variance

Animals

Blood Pressure - drug effects

Injections, Intraperitoneal

Male

Microdialysis

Nervous System Physiological Phenomena

Osmosis

Rats

Rats, Sprague-Dawley

Saline Solution, Hypertonic - pharmacology

Supraoptic Nucleus - metabolism

Vasopressins - blood

Vasopressins - metabolism

Details

Title: Subtitle: Neural input modulates osmotically stimulated release of vasopressin into the supraoptic nucleus
Creators: Mike Ludwig - Department of Physiology and Pharmacology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157, USA
Michael F Callahan
Rainer Landgraf
Alan Kim Johnson
Mariana Morris
Resource Type: Journal article
Publication Details: The American journal of physiology, Vol.270(5 Pt 1), pp.E787-792
DOI: 10.1152/ajpendo.1996.270.5.e787
PMID: 8967466
NLM abbreviation: Am J Physiol
ISSN: 0002-9513
eISSN: 2163-5773
Grant note: HL-14338 / NHLBI NIH HHS HL-43178 / NHLBI NIH HHS
Language: English
Date published: 05/1996
Academic Unit: Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
Record Identifier: 9984213271702771

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