Neural phase locking predicts BOLD response in human auditory cortex

Hiroyuki Oya; Phillip E Gander; Christopher I Petkov; Ralph Adolphs; Kirill V Nourski; Hiroto Kawasaki; Matthew A Howard; Timothy D Griffiths

doi:10.1016/j.neuroimage.2017.12.051

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Neural phase locking predicts BOLD response in human auditory cortex

Journal article

Open access

Peer reviewed

Neural phase locking predicts BOLD response in human auditory cortex

Hiroyuki Oya, Phillip E Gander, Christopher I Petkov, Ralph Adolphs, Kirill V Nourski, Hiroto Kawasaki, Matthew A Howard and Timothy D Griffiths

NeuroImage (Orlando, Fla.), Vol.169, pp.286-301

04/01/2018

DOI: 10.1016/j.neuroimage.2017.12.051

PMCID: PMC6139034

PMID: 29274745

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Abstract

Natural environments elicit both phase-locked and non-phase-locked neural responses to the stimulus in the brain. The interpretation of the BOLD signal to date has been based on an association of the non-phase-locked power of high-frequency local field potentials (LFPs), or the related spiking activity in single neurons or groups of neurons. Previous studies have not examined the prediction of the BOLD signal by phase-locked responses. We examined the relationship between the BOLD response and LFPs in the same nine human subjects from multiple corresponding points in the auditory cortex, using amplitude modulated pure tone stimuli of a duration to allow an analysis of phase locking of the sustained time period without contamination from the onset response. The results demonstrate that both phase locking at the modulation frequency and its harmonics, and the oscillatory power in gamma/high-gamma bands are required to predict the BOLD response. Biophysical models of BOLD signal generation in auditory cortex therefore require revision and the incorporation of both phase locking to rhythmic sensory stimuli and power changes in the ensemble neural activity.

Human

Broadband power

Gamma band

Phase locking

BOLD

Auditory cortex

Neurovascular coupling

Details

Title: Subtitle: Neural phase locking predicts BOLD response in human auditory cortex
Creators: Hiroyuki Oya - Department of Neurosurgery, Human Brain Research Laboratory, University of Iowa, Iowa City, IA 52252, USA
Phillip E Gander - Department of Neurosurgery, Human Brain Research Laboratory, University of Iowa, Iowa City, IA 52252, USA
Christopher I Petkov - Institute of Neuroscience, Newcastle University Medical School, Newcastle, UK
Ralph Adolphs - Division of the Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA
Kirill V Nourski - Department of Neurosurgery, Human Brain Research Laboratory, University of Iowa, Iowa City, IA 52252, USA
Hiroto Kawasaki - Department of Neurosurgery, Human Brain Research Laboratory, University of Iowa, Iowa City, IA 52252, USA
Matthew A Howard - Department of Neurosurgery, Human Brain Research Laboratory, University of Iowa, Iowa City, IA 52252, USA
Timothy D Griffiths - Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, UK
Resource Type: Journal article
Publication Details: NeuroImage (Orlando, Fla.), Vol.169, pp.286-301
DOI: 10.1016/j.neuroimage.2017.12.051
PMID: 29274745
PMCID: PMC6139034
NLM abbreviation: Neuroimage
ISSN: 1053-8119
eISSN: 1095-9572
Publisher: Elsevier Inc
Grant note: DOI: 10.13039/100000055, name: NIDCD, award: DC04290
Language: English
Date published: 04/01/2018
Academic Unit: Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984020798902771

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