Journal article
Neural synchrony indexes impaired motor slowing after errors and novelty following white matter damage
Neurobiology of aging, Vol.38, pp.205-213
02/2016
DOI: 10.1016/j.neurobiolaging.2015.10.014
PMID: 26563990
Abstract
In humans, action errors and perceptual novelty elicit activity in a shared frontostriatal brain network, allowing them to adapt their ongoing behavior to such unexpected action outcomes. Healthy and pathologic aging reduces the integrity of white matter pathways that connect individual hubs of such networks and can impair the associated cognitive functions. Here, we investigated whether structural disconnection within this network because of small-vessel disease impairs the neural processes that subserve motor slowing after errors and novelty (post-error slowing, PES; post-novel slowing, PNS). Participants with intact frontostriatal circuitry showed increased right-lateralized beta-band (12–24 Hz) synchrony between frontocentral and frontolateral electrode sites in the electroencephalogram after errors and novelty, indexing increased neural communication. Importantly, this synchrony correlated with PES and PNS across participants. Furthermore, such synchrony was reduced in participants with frontostriatal white matter damage, in line with reduced PES and PNS. The results demonstrate that behavioral change after errors and novelty result from coordinated neural activity across a frontostriatal brain network and that such cognitive control is impaired by reduced white matter integrity.
Details
- Title: Subtitle
- Neural synchrony indexes impaired motor slowing after errors and novelty following white matter damage
- Creators
- Jan R Wessel - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USAMarkus Ullsperger - Department of Neuropsychology, Otto von Guericke University, Magdeburg, GermanyHellmuth Obrig - Max Planck Institute for Cognitive and Brain Sciences, Leipzig, GermanyArno Villringer - Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, GermanEva Quinque - Max Planck Institute for Cognitive and Brain Sciences, Leipzig, GermanyMatthias L Schroeter - Max Planck Institute for Cognitive and Brain Sciences, Leipzig, GermanyKatharina J Bretschneider - Max Planck Institute for Cognitive and Brain Sciences, Leipzig, GermanyKatrin Arelin - Max Planck Institute for Cognitive and Brain Sciences, Leipzig, GermanyElisabeth Roggenhofer - Max Planck Institute for Cognitive and Brain Sciences, Leipzig, GermanyStefan Frisch - Max Planck Institute for Cognitive and Brain Sciences, Leipzig, GermanyTilmann A Klein - Max Planck Institute for Cognitive and Brain Sciences, Leipzig, Germany
- Resource Type
- Journal article
- Publication Details
- Neurobiology of aging, Vol.38, pp.205-213
- DOI
- 10.1016/j.neurobiolaging.2015.10.014
- PMID
- 26563990
- NLM abbreviation
- Neurobiol Aging
- ISSN
- 0197-4580
- eISSN
- 1558-1497
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 02/2016
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984002487502771
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