Journal article
Neural systems responding to degrees of uncertainty in human decision-making
Science (American Association for the Advancement of Science), Vol.310(5754), pp.1680-1683
12/09/2005
DOI: 10.1126/science.1115327
PMID: 16339445
Abstract
Much is known about how people make decisions under varying levels of probability (risk). Less is known about the neural basis of decision-making when probabilities are uncertain because of missing information (ambiguity). In decision theory, ambiguity about probabilities should not affect choices. Using functional brain imaging, we show that the level of ambiguity in choices correlates positively with activation in the amygdala and orbitofrontal cortex, and negatively with a striatal system. Moreover, striatal activity correlates positively with expected reward. Neurological subjects with orbitofrontal lesions were insensitive to the level of ambiguity and risk in behavioral choices. These data suggest a general neural circuit responding to degrees of uncertainty, contrary to decision theory.
Details
- Title: Subtitle
- Neural systems responding to degrees of uncertainty in human decision-making
- Creators
- Ming Hsu - Division of Humanities and Social Sciences, 228-77, California Institute of Technology, Pasadena, CA 91125, USAMeghana BhattRalph AdolphsDaniel TranelColin F Camerer
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.310(5754), pp.1680-1683
- DOI
- 10.1126/science.1115327
- PMID
- 16339445
- NLM abbreviation
- Science
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Publisher
- United States
- Grant note
- R01 MH067681 / NIMH NIH HHS P01 NS19632 / NINDS NIH HHS
- Language
- English
- Date published
- 12/09/2005
- Academic Unit
- Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984002324002771
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