Journal article
Neural tube defects and maternal intake of micronutrients related to one-carbon metabolism or antioxidant activity
Birth defects research. A Clinical and molecular teratology, Vol.94(11), pp.864-874
11/2012
DOI: 10.1002/bdra.23068
PMCID: PMC3518275
PMID: 22933447
Abstract
BACKGROUND
Maternal nutritional status has been evaluated to clarify its role in development of neural tube defects (NTDs). Maternal folate intake during pregnancy has been closely evaluated for its association with NTDs. The study objective was to examine associations between NTDs and other dietary periconceptional micronutrient intake, particularly nutrients involved in one-carbon metabolism or antioxidant activity.
METHODS
Using data from the National Birth Defects Prevention Study, 1997–2005, logistic regression models were used to estimate the relative risk of NTDs based on maternal micronutrient intake.
RESULTS
Results were stratified according to folic acid supplement use, race/ethnicity, and maternal body mass index. Analyses included 954 cases (300 with anencephaly, 654 with spina bifida) and 6268 controls. Higher intakes of folate, thiamin, betaine, iron, and vitamin A were associated with decreased risk of anencephaly among some ethnic and clinical groups. In some groups, higher intakes of thiamin, riboflavin, vitamin B6, vitamin C, vitamin E, niacin, and retinol were associated with decreased risk of spina bifida.
CONCLUSION
In addition to folic acid, other micronutrients, including thiamin, betaine, riboflavin, vitamin B6, vitamin C, vitamin E, niacin, iron, retinol, and vitamin A, may decrease the risk of NTD occurrence.
Details
- Title: Subtitle
- Neural tube defects and maternal intake of micronutrients related to one-carbon metabolism or antioxidant activity
- Creators
- Angela L Chandler - Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, ArkansasCharlotte A Hobbs - Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, ArkansasBridget S Mosley - Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, ArkansasRobert J Berry - Division of Birth Defects and Developmental Disabilities, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GeorgiaMark A Canfield - Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TexasYan Ping Qi - Division of Birth Defects and Developmental Disabilities, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GeorgiaAnna Maria Siega-Riz - Departments of Epidemiology and Nutrition, University of North Carolina School of Public Health, Chapel Hill, North CarolinaGary M Shaw - Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Palo Alto, CaliforniaNational Birth Defects Prevention Study
- Contributors
- Paul A Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- Birth defects research. A Clinical and molecular teratology, Vol.94(11), pp.864-874
- DOI
- 10.1002/bdra.23068
- PMID
- 22933447
- PMCID
- PMC3518275
- NLM abbreviation
- Birth Defects Res A Clin Mol Teratol
- ISSN
- 1542-0752
- eISSN
- 1542-0760
- Publisher
- Wiley
- Number of pages
- 11
- Language
- English
- Date published
- 11/2012
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984214684302771
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