Journal article
Neuro-evolutionary evidence for a universal fractal primate brain shape
eLife, Vol.12, 92080
09/30/2024
DOI: 10.7554/eLife.92080
PMCID: PMC11441977
PMID: 39347569
Abstract
The cerebral cortex displays a bewildering diversity of shapes and sizes across and within species. Despite this diversity, we present a universal multi-scale description of primate cortices. We show that all cortical shapes can be described as a set of nested folds of different sizes. As neighbouring folds are gradually merged, the cortices of 11 primate species follow a common scale-free morphometric trajectory, that also overlaps with over 70 other mammalian species. Our results indicate that all cerebral cortices are approximations of the
archetypal fractal shape with a fractal dimension of
= 2.5. Importantly, this new understanding enables a more precise quantification of brain morphology as a function of scale. To demonstrate the importance of this new understanding, we show a scale-dependent effect of ageing on brain morphology. We observe a more than fourfold increase in effect size (from two standard deviations to eight standard deviations) at a spatial scale of approximately 2 mm compared to standard morphological analyses. Our new understanding may, therefore, generate superior biomarkers for a range of conditions in the future.
Details
- Title: Subtitle
- Neuro-evolutionary evidence for a universal fractal primate brain shape
- Creators
- Yujiang Wang - Newcastle UniversityKaroline Leiberg - Newcastle UniversityNathan Kindred - Newcastle UniversityChristopher R Madan - University of NottinghamColline Poirier - Newcastle UniversityChristopher I Petkov - University of Iowa, Iowa Neuroscience InstitutePeter Neal Taylor - Newcastle UniversityBruno Mota - Universidade Federal do Rio de Janeiro
- Resource Type
- Journal article
- Publication Details
- eLife, Vol.12, 92080
- DOI
- 10.7554/eLife.92080
- PMID
- 39347569
- PMCID
- PMC11441977
- NLM abbreviation
- Elife
- ISSN
- 2050-084X
- eISSN
- 2050-084X
- Grant note
- MR/T04294X/1 / UK Research and Innovation EP/L015358/1 / Engineering and Physical Sciences Research Council EP/Y016009/1 / Engineering and Physical Sciences Research Council Serra-1709-16981 / Instituto Serrapilheira PQ 2017 312837/2017-8 / Conselho Nacional de Desenvolvimento Científico e Tecnológico MR/V026569/1 / UK Research and Innovation
- Language
- English
- Date published
- 09/30/2024
- Academic Unit
- Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
- Record Identifier
- 9984720691702771
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