Journal article
Neuroanatomical Correlates of Dysglycemia in Young Children With Type 1 Diabetes
Diabetes (New York, N.Y.), Vol.63(1), pp.343-353
01/2014
DOI: 10.2337/db13-0179
PMCID: PMC3868050
PMID: 24170697
Abstract
Studies of brain structure in type 1 diabetes (T1D) describe widespread neuroanatomical differences related to exposure to glycemic dysregulation in adults and adolescents. In this study, we investigate the neuroanatomical correlates of dysglycemia in very young children with early-onset T1D. Structural magnetic resonance images of the brain were acquired in 142 children with T1D and 68 age-matched control subjects (mean age 7.0 ± 1.7 years) on six identical scanners. Whole-brain volumetric analyses were conducted using voxel-based morphometry to detect regional differences between groups and to investigate correlations between regional brain volumes and measures of glycemic exposure (including data from continuous glucose monitoring). Relative to control subjects, the T1D group displayed decreased gray matter volume (GMV) in bilateral occipital and cerebellar regions (
P
< 0.001) and increased GMV in the left inferior prefrontal, insula, and temporal pole regions (
P
= 0.002). Within the T1D group, hyperglycemic exposure was associated with decreased GMV in medial frontal and temporal-occipital regions and increased GMV in lateral prefrontal regions. Cognitive correlations of intelligence quotient to GMV were found in cerebellar-occipital regions and medial prefrontal cortex for control subjects, as expected, but not for the T1D group. Thus, early-onset T1D affects regions of the brain that are associated with typical cognitive development.
Details
- Title: Subtitle
- Neuroanatomical Correlates of Dysglycemia in Young Children With Type 1 Diabetes
- Creators
- Matthew J Marzelli - Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CAPaul K Mazaika - Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CANaama Barnea-Goraly - Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CATamara Hershey - Department of Psychiatry, Department of Neurology, and Department of Radiology, Washington University in St. Louis, St. Louis, MOEva Tsalikian - Pediatric Endocrinology, The University of Iowa, Des Moines, IAWilliam Tamborlane - Pediatric Endocrinology, Yale University, New Haven, CTNelly Mauras - Pediatric Endocrinology, Nemours Children’s Clinic, Jacksonville, FLNeil H White - Department of Pediatrics, Washington University in St. Louis, St. Louis, MOBruce Buckingham - Department of Pediatrics, Stanford University, Stanford, CARoy W Beck - Jaeb Center for Health Research, Tampa, FLKatrina J Ruedy - Jaeb Center for Health Research, Tampa, FLCraig Kollman - Jaeb Center for Health Research, Tampa, FLPeiyao Cheng - Jaeb Center for Health Research, Tampa, FLAllan L Reiss - Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CADiabetes Research in Children Network (DirecNet)
- Resource Type
- Journal article
- Publication Details
- Diabetes (New York, N.Y.), Vol.63(1), pp.343-353
- DOI
- 10.2337/db13-0179
- PMID
- 24170697
- PMCID
- PMC3868050
- NLM abbreviation
- Diabetes
- ISSN
- 0012-1797
- eISSN
- 1939-327X
- Publisher
- American Diabetes Association
- Language
- English
- Date published
- 01/2014
- Academic Unit
- Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984093364502771
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