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Neuroanatomical basis of behavioral disturbances in patients with prefrontal lesions
Journal article   Open access   Peer reviewed

Neuroanatomical basis of behavioral disturbances in patients with prefrontal lesions

ANDREA Slachevsky, MARCELA Peña, CAROLINA Pérez, EDUARDO Bravo and PATRICIA Alegría
Biological research, Vol.39(2), pp.237-250
01/2006
DOI: 10.4067/S0716-97602006000200006
PMID: 16874399
url
https://doi.org/10.4067/S0716-97602006000200006View
Published (Version of record) Open Access

Abstract

The role of the frontal lobe in control of behavioral and cognitive abilities is explored in a group of 34 patients with brain lesions restricted to the prefrontal cortex. The scores in both structured behavioral questionnaires and standard neuropsychological tests were analyzed using the injured area of the frontal lobe as the independent variable. Our results show that patients with simultaneous lesions in supero_ and inferomedial areas of the prefrontal cortex exhibit higher behavioral disturbances. Bilateral lesions also are associated with greater behavioral troubles. On the contrary, cognitive abilities are globally impaired in prefrontal patients. Results are discussed in relation to current models of the organization of the prefrontal cortex and its role on behavior control
Biology

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