Neuroanatomical determinants of the sympathetic nerve responses evoked by leptin

Shannon. M Harlan; Kamal Rahmouni

doi:10.1007/s10286-012-0168-4

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Neuroanatomical determinants of the sympathetic nerve responses evoked by leptin

Journal article

Open access

Peer reviewed

Neuroanatomical determinants of the sympathetic nerve responses evoked by leptin

Shannon. M Harlan and Kamal Rahmouni

Clinical autonomic research, Vol.23(1), pp.1-7

02/2013

DOI: 10.1007/s10286-012-0168-4

PMCID: PMC3496820

PMID: 22714900

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Abstract

Leptin is an adipocyte-derived hormone that relays a satiety signal to the brain. The effect of leptin on the sympathetic nervous system is an important aspect in the regulation of energy homeostasis as well as several other physiological functions. The arcuate nucleus of the hypothalamus is considered a major site for the regulation of physiological processes by leptin. However, there is growing recognition that other hypothalamic and extra-hypothalamic brain nuclei are important for leptin regulation of physiological processes including sympathetic nerve traffic. The current review discusses the various hypothalamic and extra-hypothalamic nuclei that have been implicated in leptin-induced increase in regional sympathetic nerve activity. The continuous rise in the prevalence of obesity underscores the importance of understanding the underlying neural mechanisms regulating sympathetic traffic to different tissues to design effective strategies to reverse obesity and associated diseases.

Brain nuclei

Energy metabolism

Cardiovascular regulation

Leptin

Sympathetic nerve activity

Details

Title: Subtitle: Neuroanatomical determinants of the sympathetic nerve responses evoked by leptin
Creators: Shannon. M Harlan - Department of Pharmacology, University of Iowa Carver College of Medicine, 3135C MERF, Iowa City, IA 52242, USA
Kamal Rahmouni - Department of Pharmacology, University of Iowa Carver College of Medicine, 3135C MERF, Iowa City, IA 52242, USA; Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Clinical autonomic research, Vol.23(1), pp.1-7
DOI: 10.1007/s10286-012-0168-4
PMID: 22714900
PMCID: PMC3496820
NLM abbreviation: Clin Auton Res
ISSN: 0959-9851
eISSN: 1619-1560
Grant note: P01 HL014388 || HL / National Heart, Lung, and Blood Institute : NHLBI
Language: English
Date published: 02/2013
Academic Unit: Iowa Neuroscience Institute; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040219502771

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