Journal article
Neuroanatomy and lesion networks of central poststroke pain
Pain (Amsterdam), Vol.166(9), pp.e303-e313
09/2025
DOI: 10.1097/j.pain.0000000000003618
PMID: 40359377
Abstract
Identifying lesion sites associated with central poststroke pain (CPSP) may facilitate targeted screening for early symptoms, possibly even paving the way for preventive measures and earlier treatment initiation. Here, we test the hypothesis that damage to a nociceptive pathway extending from the brainstem to the cerebral cortex, and including white matter tracts, is associated with CPSP. We investigated the lesion locations of 72 patients with CPSP relative to poststroke comparison subjects without pain (n = 123), divided into a discovery and independent validation data set. The study included three main analyses: (1) we compared lesion intersection with our a priori region of interest (ROI) between groups with and without CPSP, (2) we performed lesion-symptom mapping to evaluate whether lesions associated with CPSP localize to the a priori ROI, and (3) we used lesion network mapping to infer the broader structural and functional connectivity patterns associated with CPSP lesions. CPSP lesions overlapped the nociceptive pathway ROI to a greater extent than comparison lesions. Lesion-symptom mapping identified a CPSP-associated region overlapping with the ventrocaudal thalamus and adjacent white matter, which was located mostly within the a priori ROI. Lesion network mapping demonstrated that lesions associated with CPSP disrupt nodes and tracts of the nociceptive pathway ROI. Interestingly, the CPSP lesion network results demonstrated connectivity to intereffector nodes of the primary motor cortex, providing a novel link between CPSP and the somato–cognitive action network. Together, these findings indicate that CPSP can be conceptualized as a lesion-associated network disruption of the nociceptive pathway and somato–cognitive action network.
Details
- Title: Subtitle
- Neuroanatomy and lesion networks of central poststroke pain
- Creators
- Hassan A. Karoam - Interdisciplinary Graduate Program in Neuroscience, University of Iowa Graduate College, Iowa City, IA, United States, Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, United StatesJoel Bruss - University of IowaKatharine Champoux - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, United StatesMarcelo Delboni Lemos - Department of Radiology, LIM-44, University of São Paulo, São Paulo, BrazilIsabelle Faillenot - Université Jean MonnetDaniel Ciampi de Andrade - Aalborg UniversityKai Hwang - University of IowaEmine Bayman - Department of Biostatistics, College of Public Health, and Department of Anesthesia, University of Iowa Carver College of Medicine, Iowa City, IA, United StatesJatin Vaidya - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, United StatesEvan M. Gordon - Research Institute of RadiologyDaniel Tranel - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, United States, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, United States, Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, United StatesJoel C. Geerling - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, United States, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, United StatesAaron D. Boes - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, United States, Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, United States, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, United States, Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, United States
- Resource Type
- Journal article
- Publication Details
- Pain (Amsterdam), Vol.166(9), pp.e303-e313
- DOI
- 10.1097/j.pain.0000000000003618
- PMID
- 40359377
- NLM abbreviation
- Pain
- ISSN
- 0304-3959
- eISSN
- 1872-6623
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Grant note
- Foundation for the National Institutes of Health: P50 MH094258, R01NS114405 National Institutes of HealthRoy J. Carver Charitable TrustKiwanis Neuroscience Research Foundation: NNF21OC0072828 Novo Nordisk
This research was partially supported by grants from the National Institutes of Health (P50 MH094258 to D.T.; R01NS114405 to A.D.B.), the Roy J. Carver Charitable Trust (to A.D.B., E.B., and J.V.), and the Kiwanis Neuroscience Research Foundation (to D.T.). D.C.A. is supported by a Novo Nordisk Grant NNF21OC0072828.
- Language
- English
- Electronic publication date
- 05/09/2025
- Date published
- 09/2025
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Psychiatry; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Biostatistics; Anesthesia; Neurology (Pediatrics); University College Courses
- Record Identifier
- 9984822965602771
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