Journal article
Neuroanatomy of cerebellar mutism syndrome: the role of lesion location
Brain communications, Vol.6(4), fcae197
07/02/2024
DOI: 10.1093/braincomms/fcae197
PMCID: PMC11250198
PMID: 39015767
Abstract
Abstract Approximately 25% of pediatric patients who undergo cerebellar tumor resection develop cerebellar mutism syndrome. Our group recently showed that damage to the cerebellar deep nuclei and superior cerebellar peduncles, which we refer to as the cerebellar outflow pathway, is associated with an increased risk of cerebellar mutism syndrome. Here, we tested whether these findings replicate in an independent cohort. We evaluated the relationship between lesion location and the development of cerebellar mutism syndrome in an observational study of 56 pediatric patients ranging from five months to 14 years of age who underwent cerebellar tumor resection. We hypothesized that individuals who developed cerebellar mutism syndrome after surgery, relative to those who did not, would have lesions that preferentially intersect with: 1) the cerebellar outflow pathway and 2) a previously generated ‘lesion-symptom map’ of cerebellar mutism syndrome. Analyses were conducted in accordance with pre-registered hypotheses and analytic methods (https://osf.io/r8yjv/). We found supporting evidence for both hypotheses. Compared to patients who did not develop cerebellar mutism syndrome, patients with cerebellar mutism syndrome (n=10) had lesions with greater overlap with the cerebellar outflow pathway (Cohen’s d=.73, p=.05), and the cerebellar mutism syndrome lesion-symptom map (Cohen’s d=1.1, p=.004). These results strengthen the association of lesion location with the risk of developing cerebellar mutism syndrome and demonstrate generalizability across cohorts. These findings may help to inform the optimal surgical approach to pediatric cerebellar tumors.
Details
- Title: Subtitle
- Neuroanatomy of cerebellar mutism syndrome: the role of lesion location
- Creators
- Jax Skye - University of Iowa, PsychiatryJoel Bruss - University of IowaSebastian Toescu - Great Ormond Street HospitalKristian Aquilina - Great Ormond Street HospitalAmanda Grafft - University of IowaGino Bardi LolaAaron D Boes - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Brain communications, Vol.6(4), fcae197
- DOI
- 10.1093/braincomms/fcae197
- PMID
- 39015767
- PMCID
- PMC11250198
- ISSN
- 2632-1297
- eISSN
- 2632-1297
- Language
- English
- Electronic publication date
- 06/05/2024
- Date published
- 07/02/2024
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Psychiatry; Pediatric Psychology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984648569802771
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