Neurobiological aspects of suicide and suicide attempts in bipolar disorder

Daniel Mathews; Erica Richards; Mark Niciu; Dawn Ionescu; Joseph Rasimas; Carlos Zarate

doi:10.2478/s13380-013-0120-7

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Neurobiological aspects of suicide and suicide attempts in bipolar disorder

Journal article

Open access

Neurobiological aspects of suicide and suicide attempts in bipolar disorder

Daniel Mathews, Erica Richards, Mark Niciu, Dawn Ionescu, Joseph Rasimas and Carlos Zarate

Translational neuroscience, Vol.4(2), pp.203-216

06/01/2013

DOI: 10.2478/s13380-013-0120-7

PMCID: PMC3840723

PMID: 24294519

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Abstract

Suicide and bipolar disorder (BD) are challenging, complex, and intertwined areas of study in contemporary psychiatry. Indeed, BD is associated with the highest lifetime risk for suicide attempt and completion of all the psychiatric conditions. Given that several clinical risk factors for both suicide and BD have been well noted in the literature, exploring the neurobiological aspects of suicide in BD may provide insights into both preventive measures and future novel treatments. This review synthesizes findings regarding the neurobiological aspects of suicide and, when applicable, their link to BD. Neurochemical findings, genes/epigenetics, and potential molecular targets for current or future treatments are discussed. The role of endophenotypes and related proximal and distal risk factors underlying suicidal behavior are also explored. Lastly, we discuss the manner in which preclinical work on aggression and impulsivity may provide additional insights for the future development of novel treatments.

Suicidal behavior

Treatment

Neurobiology

Bipolar disorder

Depression

Suicide

Glutamate

Details

Title: Subtitle: Neurobiological aspects of suicide and suicide attempts in bipolar disorder
Creators: Daniel Mathews - Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA
Erica Richards - Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA
Mark Niciu - Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA
Dawn Ionescu - Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA
Joseph Rasimas - Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA
Carlos Zarate - Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA
Resource Type: Journal article
Publication Details: Translational neuroscience, Vol.4(2), pp.203-216
DOI: 10.2478/s13380-013-0120-7
PMID: 24294519
PMCID: PMC3840723
NLM abbreviation: Transl Neurosci
ISSN: 2081-3856
eISSN: 2081-6936
Publisher: Versita
Number of pages: 14
Language: English
Date published: 06/01/2013
Academic Unit: Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984003471202771

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