Neurobiological markers of exercise-related brain plasticity in older adults

Michelle W Voss; Kirk I Erickson; Ruchika Shaurya Prakash; Laura Chaddock; Jennifer S Kim; Heloisa Alves; Amanda Szabo; Siobhan M Phillips; Thomas R Wójcicki; Emily L Mailey; Erin A Olson; Neha Gothe; Victoria J Vieira-Potter; Stephen A Martin; Brandt D Pence; Marc D Cook; Jeffrey A Woods; Edward McAuley; Arthur F Kramer

doi:10.1016/j.bbi.2012.10.021

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Neurobiological markers of exercise-related brain plasticity in older adults

Journal article

Open access

Peer reviewed

Neurobiological markers of exercise-related brain plasticity in older adults

Michelle W Voss, Kirk I Erickson, Ruchika Shaurya Prakash, Laura Chaddock, Jennifer S Kim, Heloisa Alves, Amanda Szabo, Siobhan M Phillips, Thomas R Wójcicki, Emily L Mailey, …

Brain, behavior, and immunity, Vol.28, pp.90-99

02/2013

DOI: 10.1016/j.bbi.2012.10.021

PMCID: PMC3544982

PMID: 23123199

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https://www.ncbi.nlm.nih.gov/pmc/articles/3544982View

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Abstract

► Aerobic exercise-related increases in circulating BDNF, IGF-1, and VEGF modulates temporal lobe functional brain connectivity in elderly humans. The current study examined how a randomized one-year aerobic exercise program for healthy older adults would affect serum levels of brain-derived neurotrophic factor (BDNF), insulin-like growth factor type 1 (IGF-1), and vascular endothelial growth factor (VEGF) – putative markers of exercise-induced benefits on brain function. The study also examined whether (a) change in the concentration of these growth factors was associated with alterations in functional connectivity following exercise, and (b) the extent to which pre-intervention growth factor levels were associated with training-related changes in functional connectivity. In 65 participants (mean age=66.4), we found that although there were no group-level changes in growth factors as a function of the intervention, increased temporal lobe connectivity between the bilateral parahippocampus and the bilateral middle temporal gyrus was associated with increased BDNF, IGF-1, and VEGF for an aerobic walking group but not for a non-aerobic control group, and greater pre-intervention VEGF was associated with greater training-related increases in this functional connection. Results are consistent with animal models of exercise and the brain, but are the first to show in humans that exercise-induced increases in temporal lobe functional connectivity are associated with changes in growth factors and may be augmented by greater baseline VEGF.

Aging

Exercise

Growth Factors

Functional connectivity

fMRI

Default mode network

Aerobic fitness

Details

Title: Subtitle: Neurobiological markers of exercise-related brain plasticity in older adults
Creators: Michelle W Voss - The University of Iowa, Department of Psychology, IA, United States
Kirk I Erickson - Department of Psychology, University of Pittsburgh, PA, United States
Ruchika Shaurya Prakash - Department of Psychology, The Ohio State University, OH, USA
Laura Chaddock - Beckman Institute & Department of Psychology, IA, United States
Jennifer S Kim - Beckman Institute & Department of Psychology, IA, United States
Heloisa Alves - Beckman Institute & Department of Psychology, IA, United States
Amanda Szabo - Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, IL, United States
Siobhan M Phillips - Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, IL, United States
Thomas R Wójcicki - Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, IL, United States
Emily L Mailey - Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, IL, United States
Erin A Olson - Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, IL, United States
Neha Gothe - Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, IL, United States
Victoria J Vieira-Potter - Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, IL, United States
Stephen A Martin - Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, IL, United States
Brandt D Pence - Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, IL, United States
Marc D Cook - Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, IL, United States
Jeffrey A Woods - Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, IL, United States
Edward McAuley - Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, IL, United States
Arthur F Kramer - Beckman Institute & Department of Psychology, IA, United States
Resource Type: Journal article
Publication Details: Brain, behavior, and immunity, Vol.28, pp.90-99
DOI: 10.1016/j.bbi.2012.10.021
PMID: 23123199
PMCID: PMC3544982
NLM abbreviation: Brain Behav Immun
ISSN: 0889-1591
eISSN: 1090-2139
Publisher: Elsevier Inc
Grant note: DOI: 10.13039/100000002, name: The National Institutes of Health, award: 05 R37 AG025667, RO1 AG25032
Language: English
Date published: 02/2013
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984002493002771

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